摘要
1目的 探讨慢性肝病病人外周血中一氧化氮 (NO)和肿瘤坏死因子 α(TNF- α)含量的变化及其意义。 2方法 采用 Griess法和双抗体夹心 EL ISA法测定 11例慢性迁延性肝炎 (CPH)、12例慢性活动性肝炎(CAH)、17例肝硬化 (L C)病人外周血中 NO和 TNF- α的含量 ,并与 33例正常人进行了比较。 3结果 慢性肝病病人血清中 TNF- α与 NO明显高于对照组 (t=2 .377～ 7.0 74,P<0 .0 5 ) ,且 TNF- α与 NO呈正相关 (r=0 .811,P<0 .0 1)。 4结论 TNF- α参与了肝脏的活动性病变过程 。
Objective\ To study the content of TNF α and NO and its clinical significance in the patients with chronic liver diseases.\ Methods\ Using Griess and ELISA methods, the contents of TNF α and NO in the peripheral blood of 11 patients with chronic persistent hepatitis (CPH), 12 patients with chronic active hepatitis (CAH) and 17 patients with liver cirrhosis (LC) were detected and compared with those of 33 healthy subjects.\ Results\ The contents of TNF α and NO in patients with chronic liver diseases were significantly higher than those in normal controls ( t=2.377-7.074,P <0.05). There was a positive correlation between TNF α and NO levels.\ Conclusion\ These findings shows that TNF α participates in the activity process of liver disease and NO participates in hepatocyte injury mechanism in viral hepatitis as an effective immunomolecule. [
出处
《齐鲁医学杂志》
2000年第3期175-176,共2页
Medical Journal of Qilu
关键词
肝炎
肝硬化
肿瘤坏死因子Α
一氧化氮
hepatitis
liver cirrhosis
tumor necrosis factor
nitric oxide
