摘要
1目的 观察神经生长因子对新生儿缺氧缺血性脑病 (HIE)疗效。 2方法 将足月 HIE新生儿随机分为 A,B组 ,A组单用脑活素 ,B组用神经生长因子及脑活素治疗 ,并给予早期干预。生后 5 d内、发病后 18～ 2 5 d,90～ 180 d行头颅 CT平扫 ,发病后 18～ 2 5 d行新生儿行为神经测定 (NBNA) ,90～ 180 d行 Gesell发育量表检查。 3结果 B组在头颅 CT恢复程度、NBNA测定、智力测定等方面明显优于 A组 (χ2 =5 .31～ 9.11,P<0 .0 5 ;t=6 .95 ,P<0 .0 1)。 4结论 神经生长因子对促进
Objective\ To observe the therapeutic effect of nerve growth factor(NGF) on neonatal hypoxic ischemic encephalopathy(HIE).\ Methods\ One month or older newborns with HIE were randomly divided into group A and group B. The newborns in group A were treated with cerebrolysin only, those in group B were treated with the combination of NGF and cerebrolysin and early management was done. CT scan was done within five days of life, and 18-25 days and 90-180 days after the onset of the disease. And neonatal behavior neurological assessment(NBNA) was performed during 18-25 days after the onset of the disease. IQ values were determined by Gesell Development Level Chart.\ Results\ The newborns in group B showed notably better results than those in group A in terms of the degree of recovery shown by skull CT, NBNA determination, and intelligence determination.\ Conclusion\ NGF has notable effect in promoting recovery of the function of central nervous system. [
出处
《齐鲁医学杂志》
2000年第3期181-182,共2页
Medical Journal of Qilu
关键词
缺氧缺血性脑病
神经生长因子
新生儿
hypoxic ischemic encephalopathy
infant, newborn
nerve grouth factors
tomography, X ray computer
