摘要
目的:观察剖宫产手术患者围术期应用3代不同头孢菌素预防感染的疗效,评价用药合理性,以进一步指导临床合理用药。方法:采用回顾性调查方法,对2008年1月1日—2010年12月31日青海省妇幼保健院产科剖宫产手术且单独使用了1种头孢菌素的患者进行分组,其中A组使用第1代头孢菌素注射用头孢唑林钠,B组使用第2代头孢菌素注射用头孢呋辛钠,C组使用第3代头孢菌素注射用头孢哌酮钠,3组各抽取200份病历进行回顾性分析。A组:围术期静脉滴注头孢唑林钠2.0 g,每12h给予1次,术后用药3～5 d;B组:围术期静脉滴注头孢呋辛钠2.25 g,每12 h给予1次,术后用药3～5 d;C组:围术期静脉滴注头孢哌酮钠2.0 g,每12 h给予1次,术后用药3～5 d,观察这3代不同头孢菌素预防感染的疗效。结果:使用了不同头孢菌素后,3组患者的白细胞计数、中性粒细胞百分比、血红蛋白、并发症、体温及伤口愈合情况比较,差异均无统计学意义;C组有2例患者发生切口感染。结论:3代头孢菌素预防剖宫产手术感染的疗效比较,差异无统计学意义,第3代头孢菌素并未显示出优越性,且有个别患者发生切口感染。临床应切实遵循有效、安全、经济的原则,合理应用抗菌药物。
OBJECTIVE：To investigate the preventive efficacy of three generations cephalosporins against wound infection in patients undergoing caesarean section and evaluate the rationality of the drug use for clinical reference of rational drug use. METHODS： Totally 600 patients undergoing cesarean section surgery from Jan. 1, 2008 to Dec. 31, 2010 in Qinghai Maternal and Child Health Care Hospital were randomly assigned to three groups （each 200 cases）, namely Group A in which group first generation cephalosporins cefazolin sodium for injection （2. 0 g ） was administered by iv gtt perioperatively q12 for 3-5 days after operation; Group 2 in which group second generation cephalosporins cefuroxime sodium for injection （2. 25 g） was administered by iv gtt perioperatively q12 for 3-5 days after operation; and Group C in which group third generation cephalosporins cefoperazone sodium for injection （2. 0 g） was administered by iv gtt perioperatively q12 for 3-5 days after operation. The curative efficacy in the three groups was followed. RESULTS： No statistically significant differences were noted among the three groups after treatment with regard to WBC, N% （percent of neutrophil）, hemoglobin （Hb）, complications, body temperature, wound healing. However, wound infection was noted in 2 cases of Group C. CONCLUSION： There were no statistically significant differences among the three generations cephalosporins with regard to preventive efficacy against wound infection in patients undergoing cesarean section. The third generation cephalosporins was found to be of no superiority to other generations of cephalosporins, on the contrary, certain patient presented with wound infection after treatment with the third generation cephalosporins. It is important to follow the effective, safe and economic drug use principle in clinic to achieve rational use of antibacterials.
出处
《中国医院用药评价与分析》
2013年第3期257-260,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
头孢菌素
剖宫产手术
预防感染
疗效观察
Cephalosporims
Cesarean section
Infection prevention
Observation of efficacy
