摘要
目的通过观察TGF-β1和MMP-2在口腔鳞状细胞癌的表达情况,探讨研究其与肿瘤浸润和转移相关性。方法运用免疫组化染色方法观察TGF-β1和MMP-2在36例手术切除的口腔鳞状细胞癌组织中的表达情况,并与正常组织中的表达做对比,比较有无转移者的TGF-β1和MMP-2表达情况,分析二者表达与肿瘤浸润和转移的相关性。结果癌组织组TGF-β1和MMP-2阳性表达明显高于正常组织,相比均有统计学意义(P<0.05);淋巴结转移者与无转移者TGF-β1灰度值分别为59.47%±3.26%、17.51%±1.64%,MMP-2分别为76.92%±5.48%、14.22%±1.35%,比较均有显著性差异(P<0.05);相关性分析显示二者表达与肿瘤浸润转移显著相关。结论 TGF-β1和MMP-2在口腔鳞状细胞癌中高表达,其与肿瘤浸润和转移密切相关。
Objective To explore the correlation of TGF - 131 and MMP - 2 with tumor invasion and metastasis by observing their expression in oral squamous cell carcinoma. Methods To observe the expression of TGF - 131 and MMP - 2 in oral squamous cell carci- noma in 36 cases of surgical resection by immunohistochemical staining, and to compare with normal tissue. Results TGF - 131 and MMP - 2 positive expression in cancer tissue was significantly higher than that in normal tissue （P 〈0.05 or 0.01 ）. TGF - 131 gray value of lymph node metastasis patients and no metastasis patients were 59.47% ＋ 3.26% and 17.51% ＋ 1.64% , the value of MMP -2 were 76.92% ~ 5.48% and 14.22% ~ 1.35% , and there was significant difference between two groups （ P 〈 0.05 ）. The correlation analysis showed that the expression of TGF - 131 and MMP -2 has significantly correlation with tumor invasion and metastasis. Conclusion High expression of TGF - β1 and MMP - 2 in oral squamous cell carcinoma can be obviously related to tumor invasion and metastasis.
出处
《医学研究杂志》
2013年第3期79-82,共4页
Journal of Medical Research
基金
浙江省自然科学基金资助项目(Y208274)
