摘要
目的探讨术后辅助治疗的乳腺癌患者在辅助治疗期间体重变化对其预后的影响。方法收集2004年2月至2006年4月期间186例女性乳腺癌患者的临床资料。根据辅助治疗期间的体重变化将全部患者分为减少组、稳定组和增加组,比较3组的临床病理参数。采用Log-rank检验及Cox比例风险模型分析影响无病生存期(DFS)预后的因素。结果体重变化与年龄、身体质量指数、辅助放疗、临床分期、吸烟史和消化道反应有关,而与相关疾病史和内分泌治疗无关。单因素分析显示,体重变化与DFS有关;Cox比例风险模型显示,体重变化是DFS的独立预测因素(χ2=12.107,P=0.002)。结论对于术后辅助治疗的乳腺癌患者,辅助治疗期间体重变化是影响其预后的重要因素,体重增加将导致DFS缩短。
Objective To investigate the influence of weight changes during adjuvant therapy on the prognosis of breast canc-er patients after operation. Methods The clinical data of 186 cases with breast cancer were collected. According to the weight change during adjuvant therapy, 186 patients were divided into 3 groups： weight loss group, weight stable group and weight gain group. The clinicopathological characteristics were analyzed among groups. Log-rank test and Cox proportional hazard model analysis were pre- formed to make univariate and multivariate analysis on disease-free survival（DFS）. Results Weight change was associated with age, body mass index, radiotherapy, clinical stage, smoking and gastrointestinal reaction. Univariate analysis showed that weight changewas associated with DFS and Cox proportional hazard model analysis showed that during adjuvant therapy weight gain was an independ- ent prognostic factor associated with poorer clinical outcomes in breast cancer patients（X^2 = 12. 107 ,P = 0. 002）. Conclusion Weight change during adjuvant therapy was an independent negative prognostic factor for DFS in breast cancer patients. Therefore, maintaining normal weight may contribute to the prevention of breast cancer.
出处
《临床肿瘤学杂志》
CAS
2013年第3期220-223,共4页
Chinese Clinical Oncology
基金
科技部基金资助项目(2012ZX09303016-002)
关键词
乳腺癌
体重变化
预后
Breast cancer
Weight change
Prognosis
