摘要
目的探讨拉米夫定联合自拟复方乙肝汤治疗慢性乙型肝炎的临床疗效。方法选择52例慢性乙型肝炎患者作为研究对象，并按随机数字表法平均分为对照组与联合组，每组26例。在一般治疗的基础上，对照组采用口服拉米夫定治疗，联合组在对照组治疗基础上给予自拟益肝汤治疗。观察并比较两组治疗有效率、病毒血清学及核酸应答率以及对细胞免疫状态的影响。结果与对照组相比，联合组治疗总有效率显著升高，由73．08％升高至84．62％（P〈0．05）；病毒血清学应答率及核酸应答率均显著升高，分别由23．08％及65．38％提高至38．46％及88．46％；此外，与治疗前相比，所有患者CD4^＋T细胞比例均显著升高（P〈0．05）；联合组CD8^＋T细胞比例显著降低（P〈0．05）；与治疗前相比，两组CD4^＋／CD8^＋比例显著升高，且以联合组升高更为显著（P〈0．05）。结论自拟益肝汤联合拉米夫定治疗慢性乙型肝炎疗效肯定，能够改善病毒核酸及血清学反应性、细胞免疫状态，优于单用拉米夫定。
Objective To explore the clinical effect of combination therapy of lamivudine and Yigan decoction in treatment of chronic hepatitis B. Methods 52 patients with chronic hepatitis B were selected and divided into control group and combination group randomly according to the digital table. Based on regular treatments, control group received treatment of lamivudine, and based on treatment of control group, combination group received treatment of Yigan decoction. Treatment efficacy, viral serological response rate, viral nucleic acid response rate and cellular immunity status were observed and compared. Results Compared with control group, treatment efficacy increased significantly from 73.08% to 84.62% （P 〈 0.05 ） ; viral serological response rate and viral nucleic acid response rate increased significantly at the same time, from 23.08% to 65.38% and from 38.46% to 88.46% respectively （P 〈 0.05） ; Composition of CD4 ^＋T cells increased significantly in all patients after treatment, but more significantly in combination group （P 〈 0.05 ） ; Composition of CD8^＋ T cells decreased significantly in combination group after treatment （ P 〈 0. 05） ;ratio of CD4^＋/CD8^＋ increased significantly after treatment in all patients but more significantly in combination group （P 〈 0.05 ）. Conclusion Combination therapy of lamivudine and Yigan decoction is an ideal treatment of chronic hepatitis B, which can improv viral serological response, viral nucleic acid response and cellular immunity status, better than application of lamivudine alone.
出处
《中国基层医药》
CAS
2013年第8期1143-1145,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
拉米夫定
益肝汤
肝炎
慢性
肝炎
乙型
免疫
细胞
Lamivudine
Yigan Decoction
Hepatitis, chronic
Hepatitis B
Immunity, cellular
