摘要
目的观察康复新液联合庆大霉素直肠滴注治疗溃疡性结肠炎的疗效。方法将92例溃疡性结肠炎患者随机分为两组,治疗组给予康复新液50mL加庆大霉素8×104U加入0.9%氯化钠液50mL充分混合后,加温至38℃左右,缓慢直肠滴入,每日早晚各一次,15d一个疗程,间隔5d行下一疗程,连用2个疗程,病情稳定后口服美沙拉嗪缓释片1g/次,1次/d,巩固疗效。对照组口服美沙拉嗪缓释片1g/次,3次/d,病情稳定后逐渐减量至治疗组剂量巩固治疗。观察治疗过程中两组患者不良反应发生情况,治疗结束后评价两组的治疗疗效及总有效率。结果对照组总有效率67.4%,治疗组总有效率80.4%,治疗组明显优于对照组,两组差异有统计学意义(P<0.05)。两组患者均有轻微胃部不适、恶心症状发生,治疗组3例,对照组2例,均未影响治疗。结论康复新液联合庆大霉素直肠滴注治疗溃疡性结肠炎有较好的疗效,且不良反应轻微,值得临床推广。
Objective To observe the clinical effect of Kangfuxin Liquid（KL） combined with gentamicin by rectum drop on the treatment of ulcerative colitis.Methods Patients with ulcerative colitis（92 cases） were randomly divided into two groups.In the treatment group,KL（50 mL） and gentamicin（8×104 U） were added into 0.9% sodium chloride liquid（50 mL）,mixed thoroughly,and heated up to about 38 ℃.The KL combined with gentamicin was dropped into rectum slowly,twice daily,each time in the morning and evening,15 d as one course,and after 5 d broke,the next course began,for continuous two courses.When the condition of patients was stable,they took Mesalazine Sustained-release Tablets（1 g） orally once daily to enhance the curative effect.In control group,patients took Mesalazine Sustained-release Tablets orally,1 g once for three times a day.When the condition of patients was stable,the dosage was reduced to that in the treatment group to consolidate the curative effect.The adverse reactions of patients were observed during the treatment,and the therapeutic efficacy and total efficiency were evaluated in the end of the treatment.Results The efficiency of control and treatment groups was 67.4% and 80.4%,respectively,with the significant difference between the two groups（P 0.05）.Patients in both groups had mild stomach upset and nausea symptoms（3 cases in the treatment group and 2 cases in the control group）,which did not affect on the treatment efficacy.Conclusion：KL combined with gentamicin has a better therapeutic effect on ulcerative colitis with less adverse reactions,which could be worth of spreading in clinic.
出处
《现代药物与临床》
CAS
2013年第2期217-219,共3页
Drugs & Clinic
