期刊文献+

替罗非班应用时间对急性ST段抬高型心肌梗死患者PCI围术期临床疗效及短期预后的影响 被引量:7

下载PDF
导出
摘要 目的探讨替罗非班应用时间对急性ST段抬高型心肌梗死(ASTEMI)患者介入治疗围术期临床疗效及短期预后的影响。方法将125例行经皮冠脉介入治疗(PCI)的ASTEMI患者随机分为两组,行PCI时观察组先冠脉内注入替罗非班,随之持续静滴,并随机分为用药12、24、36 h三个亚组;对照组向冠脉内注射等量0.9%氯化钠注射液。PCI后即刻用TIMI血流及心肌灌注分级评价患者的心肌血流,观察PCI后180 d的心脏不良事件及出血发生情况。结果 PCI后对照组及观察组TIMI血流达到3级者比较,P>0.05;但两组TIMI心肌灌注分级达到3级者比较,P<0.05。观察组内三个亚组TIMI血流、心肌灌注分级达到3级者比较,P均>0.05。PCI后180 d对照组发生心脏不良事件者多于观察组,出血者少于观察组,观察组内36 h组发生出血者多于12 h组、24 h组。结论ASTEMI患者行PCI时,静脉及冠脉内应用替罗非班可减少其心脏不良事件发生,改善短期预后。短时间静脉应用替罗非班可达到同样的临床效果,且可减少出血发生。
出处 《山东医药》 CAS 2012年第45期36-38,共3页 Shandong Medical Journal
  • 相关文献

参考文献9

  • 1Theroux P, Alexander J, Dupuis J, et al. Upstream use of tirofiban in patients admitted for an acute coronary syndrome in hospitals with or without facilities for invasive management [J]. Am J Cardiol, 2001,87(4) :375-380.
  • 2Gibson CM, Ryan KA, Kelley M, et al. Methodologic drift in the assessment of TIMI grade 3 flow and its implications with respect to the reporting of angiographic trial results[ J]. Am Heart J, 1999, 137(6) :1179-1184.
  • 3Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI myocardial perfusion grade to mortality after administration of throm- bolytic drugs[J]. Circulation, 2000,101 (2) :125-130.
  • 4Razakjr OA, Tan HC, Yip WL, et al. Predictors of bleeding complications and thrombocytopenia with the use of abciximab during percutaneous coronary intervention [ J ]. J Interv Cardiol, 2005,18 ( 1 ) :33-37.
  • 5ten Berg JM, van' t Hof AW, Dill T, et al. Effect of early, pre-hospital initiation of high bolus dose tirofiban in patients with ST-seg- ment elevation myocardial infarction on short-and long-term clinical outcome [ J ]. J Am Coil Cardiol, 2010,55 ( 22 ) : 2446 -2455.
  • 6Friedland S, Eisenberg MJ, Shimony A. Meta-analysis of randomized controlled trials of intracoronary versus intravenous administration of glycoprotein Ⅱb/Ⅲa inhibitors during percutaneous coronary intervention for acute coronary syndrome[J]. Am J Cardiol, 2011, 108(9) :1244-1251.
  • 7Huynh T, Piazza N, DiBattiste PM, et al. Analysis of bleeding complications associated with glycoprotein Ⅱb/Ⅲa receptors blockade in patients with high-risk acute coronary syndromes: insights from the PRISM-PLUS study[J]. Int J Cardiol. 2005. 100( 1 ) .73-7R.
  • 8商德亚,周轶,胡波,来庆友.盐酸替罗非班在急性心肌梗死介入术中的应用及机制探讨[J].山东医药,2008,48(29):27-29. 被引量:5
  • 9Marciniak SJ, Mascelli MA, Furman MI, et al. An additional mechanism of action of abciximab : dispersal of newly formed platelet aggregates [ J ]. Thromb Haemost, 2002,87 ( 6 ) : 1020 -1025.

二级参考文献4

  • 1Naruko T, Ueda M, Haze K,et al. Neutrophil infiltration of cuoprit lesions in acute coronary syndromes[ J]. Circulation, 2002, 106 ( 23 ) :2894-2900.
  • 2Azar R, Badaoui G, Sarkis A, et al. Effects of tirofiban and statins on high sensiitivity Creactive protein, interleukin-6, and soluble CD40 ligand following percutaneous coronary interventions in patients with stable coronary artery dlsease[J]. Am J Cardiol, 2005, 95(2) :236-240.
  • 3Stone GW, Grines CL, Cox DA, et al. Comparision of angioplasty with stenting, with or without abciximab, in acute myocardial infarction[J]. N Eng J Med, 2002,346(13):957-966.
  • 4纪求尚,张运,朱园园,安丰双,王荣.促凝因子在急性冠脉综合征预后中的作用[J].山东大学学报(医学版),2003,41(3):271-274. 被引量:3

共引文献4

同被引文献66

引证文献7

二级引证文献142

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部