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斑秃皮损的炎症浸润和毛囊周期改变特征 被引量:10

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摘要 目的观察斑秃皮损炎症细胞的分布情况以及毛囊周期改变特点,初步探讨嗜酸性粒细胞和肥大细胞在斑秃皮损形成中发挥的作用。方法回顾分析136例斑秃患者临床表现、实验室检查、皮损病理改变,对组织片进行吉姆萨和免疫组化染色,观察嗜酸性粒细胞、肥大细胞、T淋巴细胞的分布特点,以及毛囊周期改变特点。结果 73.5%(100/136)斑秃患者的脱发皮损可见毛囊周围蜂窝状炎症浸润,多为病程短、处于疾病活动阶段患者。47.8%(65/136)斑秃患者存在嗜酸性粒细胞浸润,其中弥漫型斑秃患者皮损发生的概率较高。真皮浅深层比较,肥大细胞的数目及活化比例在深层毛囊周围多于浅层毛囊,而在浅深层血管周围则无区别。在浅层血管周围的肥大细胞数目以及深层毛囊活化肥大细胞数与血清IgE呈正相关关系。血管周围的真皮浅层CD8+T淋巴细胞浸润和真皮深层血管周围CD3+、CD4+T淋巴细胞浸润在活动期高于稳定期皮损。毛囊的终毛/毳毛比例方面,亚全秃/全秃/普秃患者较斑片型、弥漫型为低,病程大于2年较病程小于3个月者的比例低。脱发面积≤50%患者的终毛/毳毛比例均高于脱发面积76%~100%组。结论斑秃皮损中嗜酸性粒细胞、肥大细胞和CD8+T淋巴细胞浸润与斑秃毛囊终毛/毳毛比例降低和疾病活动性相关,真皮浅层血管周围的炎症浸润明显,说明这些细胞和真皮浅层在斑秃发病起重要作用。
出处 《广东医学》 CAS CSCD 北大核心 2013年第6期867-871,共5页 Guangdong Medical Journal
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共引文献51

同被引文献153

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