摘要
目的:比较竹叶柴胡与北柴胡解热镇痛作用的差异。方法:采用2,4-二硝基苯酚致热大鼠模型比较2种柴胡水煎液的解热作用;采用醋酸扭体试验及热板法比较2种柴胡水煎液及醇提液的镇痛作用。结果:竹叶柴胡和北柴胡的水煎液均具有明显的解热作用,两者解热作用没有显著性差异(P>0.05);醋酸扭体试验的结果表明竹叶柴胡和北柴胡的水煎液、醇提液均有镇痛作用,且两者差异没有显著性;热板法试验结果表明2种柴胡的水煎液有镇痛作用且无明显差异(P>0.05),但醇提液无明显镇痛作用。结论:竹叶柴胡与北柴胡解热镇痛作用相似。
OBJECTIVE To compare the antipyretic and analgesic effects between Bupleurum chinense EIC. and Bupleurum marginatum Wall. ex DC. METHODS The antipyretic effects of Bupleurum decoction were observed by 2,4- dinitrophenolinduced rat pyrexia, and the analgesic effect was verified by the test of HAc-induced writhing response in mice and hot-plate. RESULTS The decoction of Bupleurum chinense DC. and Bupleurum marginatum Wall. ex DC. all showed significant antipyretic effects, and there was no significant difference between them （P〉0. 05） ; Both the decoction and alcohol extract of Bupleurum chinense DC. and Bupleurum rnarginatum Wall. ex DC. possessed the analgesic effect in the test of HAc-induced writhing response; The decoction of Bupleurum chinense DC. and Bupleurum marginatum Wall. ex DC. all showed the analgesic effect in the test of hot-plate and there were no significant differences （P〉0.05）, but alcohol extracts of them had no significant analgesic effect. CONCLUSION There were similar antipyretic and analgesic effects between Bupleurum chinense DC.and Bupleurum marginaturn Wall. ex DC.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第7期526-529,共4页
Chinese Journal of Hospital Pharmacy
基金
国家科技部2010年度科技型中小企业技术创新基金(编号:10C26214204534)
关键词
北柴胡
竹叶柴胡
解热
镇痛
Bupleurum chinense DC.
Bupleurum marginatum Wall. ex DC.
antipyretic effect
analgesic effect
