摘要
目的观察磷酸肌酸钠对急性心肌梗死PCI术后的心肌保护作用。方法 200例急性ST段抬高型心肌梗死均于急诊行冠脉内支架植入术后收入EICU,随机分为治疗组100例[男67例、女33例,平均年龄(61.7±10.4)岁]和对照组100例[男69例、女31例,平均年龄(59.3±11.2)岁]。于PCI术后,对照组给予常规药物治疗,治疗组在常规药物治疗基础上给予静点磷酸肌酸钠治疗7 d。检测两组患者术前及术后血清中磷酸肌酸激酶(creatine kinase,CK)、磷酸肌酸激酶同工酶(creatine kinaseisoenzyme,CK-MB)、肌钙蛋白I(troporin T,cTnI)、超敏C反应蛋白(hypersensitive C-reaction proteion,hs-CRP)的水平和左室射血分数(left ventricular ejection fraction,LVEF)。结果治疗组术后血清CK、CK-MB、cTnI、hs-CRP含量均明显低于对照组,左室射血分数高于对照组,两组均有统计学差异(P<0.05)。结论急性心肌梗死PCI术后应用磷酸肌酸钠对心肌具有一定的保护作用。
Objective To observe the myocardial protective effects of creatine phosphate sodium in patients with acute myocardial infarc- tion after percutaneous coronary intervention. Methods A total of 200 patients with acute ST segment elevation myocardial infarction successfully treated with coronary stent implantation were randomly assigned into two groups：the treatment group （100 cases）comprised 67 men and 33 women with average age of（ 61.7±10.4 ）years, the control group（ 100 cases） comprised 64 men and 36 women with aver- age age of（ 59.3±11.2） years. The control group was only treated with routine drug therapy after PCI. The treatment group was treated with routine drug therapy combined with 7 days of intravenous creatine phosphate sodium treatment after PCI. Before and after PCI crea- tine kinase （ CK）, creatine kinase isoenzyme （ CK-MB ）, troporin I （ cTnl ）, hypersensitive C -reaction proteion （hs-CRP） and left ventricular ejection fraction （LVEF） were monitored. Results The content of serum CK, CK-MB, cTnI and hs-CRP in the treatment group was lower than that in the control group. Left ventricular ejection fraction（LVEF） in the treatment group was higher than that in the control group. The differences were statistically significant （ All P 〈 0.05 ）. Conclusion The application of creatine phosphate sodium in patients with acute myocardial infarction after PCI has a protective effect on myocardium.
出处
《安徽医药》
CAS
2013年第4期648-650,共3页
Anhui Medical and Pharmaceutical Journal
关键词
磷酸肌酸钠
急性心肌梗死
经皮冠状动脉介入术
心肌保护
creatine phosphate sodium
acute myocardial infarction
percutaneous coronary intervention
myocardial protection
