摘要
目的系统评价结核分枝杆菌分泌性酸性磷酸酶(TB-SA)检测对结核病的诊断价值。方法计算机检索CNKI、万方、维普、Medline、Embase、CochraneLibrary等数据库,筛选关于TB-SA检测对结核病诊断价值的中、英文文献并进行系统评价。对纳入的文献,采用诊断精确性研究的质量评估方法(QUADAS)进行质量评价,并用Meta-Disc1.4软件进行meta分析。结果共纳入符合要求的文献13篇,合并敏感度为0.70(95%CI:0.69～0.72),合并特异度为0.83(95%CI:0.82～0.85),合并阳性似然比为4.43(95%CI:3.32～5.92),合并阴性似然比为0.35(95%CI:0.30～0.42),合并诊断优势比为14.33(95%CI:9.17～22.37),汇总受试者工作特征曲结(SROC)下面积为0.8324。结论 TB-SA检测对结核病具有一定的诊断价值,可以辅助结核病的诊断。
Objective To evaluate the accuracy of tuberculosis secreted acid phosphatase （TB-SA） test in the diagnosis of tuberculosis. Methods After a systematic review in CNKI, WANFANG DATA, VIP DATA, Medline, Embase and Cochrane Library, sensitivity, specificity and other measures of accuracy of TB-SA test in the diagnosis of tuberculosis were pooled using random effects models. Quality assessment for studies of diagnostic anuracy studies （QUADAS） was used to evaluate the quality of included studies. Summary receiver operating characteristic curves were used to summarize overall test performance. Statistical analysis was performed by employing Meta-Disc 1.4 software. Results Thirteen studies were included. The summary estimates for TB-SA test in the diagnosis of extrapulmonary tuberculosis were sensitivity 0.70 （95 % CI：0.69 - 0.72 ）, specificity 0.83 （95% CI：0.82 - 0.85 ）, positive likelihood ratio 4. 674.43 （95% CI ： 3.32 - 5.92 ）, negative likelihood ratio 0.35（95% CI：0.30 -0.42）, diagnostic odds ratio 14.33（95% CI：9.17 -22.37）, and the AUC of SROC was 0.8324. Conclusions TB-SA test can be an assistant method in diagnosing tuberculosis.
出处
《中华肺部疾病杂志（电子版）》
CAS
2013年第2期11-14,共4页
Chinese Journal of Lung Diseases(Electronic Edition)
