摘要
目的:系统评价基质金属蛋白酶-9对恶性胸腔积液的诊断价值。方法:在Medline、Embase、中国生物医学文献数据库、中国生物医学期刊文献数据库等数据库进行全面检索,查找利用基质金属蛋白酶-9诊断恶性胸腔积液的文献。利用QUADAS评分工具评价纳入文献的质量。数据分析采用Meta-Disc1.4软件,计算合并敏感度、特异度、阳性似然比、阴性似然比、诊断优势比及其95%CI。绘制汇总受试者工作特征曲线,对基质金属蛋白酶-9的诊断准确性进行综合评估。结果:共有7篇文献613例研究对象纳入本次Meta分析,分析结果显示基质金属蛋白酶-9对恶性胸腔积液的合并诊断价值分别为:敏感度为75%[95%CI(0.70,0.79)],特异度为75%[95%CI(0.70,0.80)],阳性似然比为3.53[95%CI(2.09,5.97)],阴性似然比为0.34[95%CI(0.28,0.41)],诊断比值比为11.00[95%CI(6.09,19.84)]。汇总受试者工作特征曲线下面积为0.82。结论:基质金属蛋白酶-9在恶性胸腔积液的诊断中具有一定的临床价值,其检测结果的解读需要综合考虑患者的临床症状和其他检测指标。
Objective： To assess the value of matrix metalloproteinase-9 （ MMP-9 ） in the diagnosis of malignant pleural effusion （ MPE ） . Method： A systematic review was conducted in Medline, Embase, Chinese Bio-medicine Database, and China Hospital Knowledge Database to identify relevant studies on evaluation of MMP-9 in the diagnosis of MPE.The methodological quality of each study was assessed by QUADAS.Statistical analysis was performed with Meta-Disc 1.4 software.The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and 95% CI were calculated.Summary receiver operating characteristic （ SROC ） curve was made and the area under the curve （ AUC ） was calculated. Result： Seven studies with 613 subjects met the inclusion criteria for present analysis.The summary estimates for MMP-9 in the diagnosis of MPE were： sensitivity 75% （ 95%CI 0.70, 0.79 ）, specificity 75% （ 95%CI 0.70, 0.80 ）, positive likelihood ratio 3.53 （ 95%CI 2.09, 5.97 ）, negative likelihood ratio 0.34 （95%CI 0.28, 0.41 ）, diagnostic odds ratio 11.00 （95%CI 6.09, 19.84 ）, and AUC was 0.82.Conclusion： MMP-9 plays a role in the diagnosis of MPE, while the results of MMP-9 assays should be interpreted in parallel with clinical symptoms and other test results.
出处
《中国医学创新》
CAS
2013年第11期143-145,共3页
Medical Innovation of China
