摘要
目的:探讨血小板内皮细胞黏附因子-1(PECAM-1)基因多态性与高血压的关系。方法:采用病例-对照研究,应用PCR分析技术对武汉地区352例高血压患者(高血压组)和500例健康对照人群(对照组)PECAM-1基因的第3、8、12号外显子区单碱基突变多态性(等位基因和基因型频率)进行分析。结果:与对照组比较,高血压组125Leu、563Ser和670Arg等位基因频率及125Leu/Leu、670Arg/Arg基因型频率差异具有统计学意义。在高血压伴冠心病组及3级高血压组中,125Leu/Leu、670Arg/Arg基因型频率明显高于其他组人群。563Ser和670Arg位点间存在着连锁不平衡现象。结论:PECAM-1第3、12外显子Val125Leu和Gly670Arg的基因突变不仅与高血压发病有关,可能与高血压的靶器官损害及血压高低也有联系。
Objective：To investigate the association of polymorphism of platelet endothelial cell adhesion molecule-1（PECAM-1） gene with hypertension. Method：In this study,the polymorphism in PECAM-1 gene was detected by PCR method（polymerase chain reaction） among 852 subjects,including 352 patients with hypertension and 500 controls. Result：The frequencies of 125Leu,563Ser and 670Arg alleles and 125Leu and 670Arg genotype were significant different between case and control group respectively.Among the subjects of hypertension and coronary heart disease,the frequencies of 125Leu and 670Arg genotype were higher than others.A similar trend was observed on the group of severe hypertension.The polymorphisms of 563Ser and 670Arg were in link age disequilibrium with each other. Conclusion：The 125Leu and 670Arg genotype of PECAM-1 maybe not only novel genetic risk factor of hypertension in Chinese,but also related with hypertensive target organ damage and blood pressure levels.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第4期283-286,共4页
Journal of Clinical Cardiology
关键词
高血压
血小板内皮细胞黏附因子-1
单核苷酸多态性
hypertension
platelet endothelial cell adhesion molecule-1
single nucleotide polymorphism
