摘要
评价抗磷脂抗体（APLA）与视网膜静脉阻塞（RVO）的相关性。方法计算机检索Pubmed、中国生物医学文献数据库、中国知网全文数据库、维普数据库、万方数据库，同时追索纳入文献的参考文献。检索时限均为从建库至2012年8月1日。由2位研究者按照纳入和排除标准筛选文献、提取资料并评价质量后，采用Stata11．0软件进行荟萃分析。结果共纳入12个病例对照研究，合计1324例研究对象。其中RVO组505例，对照组819人。合并分析结果显示，任意APLA、抗心磷脂抗体、狼疮凝固抑制物与RV0相关性的比值比及95％置信区间分别为5．01、3．33-7．53，4．38、2．38-8．05，1．72、0．73-4．04。任意APLA、抗心磷脂抗体与视网膜中央静脉阻塞相关性的比值比及95％置信区间分别为4．80、2．59-8．88，6．02、2．06-17．63。任意APLA、抗心磷脂抗体、狼疮凝固抑制物与视网膜分支静脉阻塞相关性的比值比及95％置信区间分别为4．22、1．67-10．63，3．69、1．32-10．32，2．07、0．79-5．41。结论APLA可能增加RVO的危险性，尤其是抗心磷脂抗体，对预测RVO有一定作用，对RVO高危患者有必要对其进行筛查。
Objective To evaluate the correlation between antiphospholipid （APLA） antibodies and retinal vein occlusion （RVO）. Methods A computerized search was conducted in the Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, VIP database, Wanfang Database combined with manually searching of literature reference proceedings. The search time was ranged from establishment of each database to August 1st, 2012. After the data extraction, quality of RCT was assessed. The meta analysis was performed by Stata 11.0. Results In total, 12 case-control studies （1324 subjects） that fulfilled the eligibility criteria were included in the meta-analysis involving 505 patients in RVO group and 819 subjects in control group. The odds ratio （OR） and 95% confidence interval （CI） of APLA, anticardiolipin antibodies （ACA）, lupus coagulation inhibitor and RVO were 5.01 and 3.33 - 7.53, 4.38 and 2.38 -- 8.05, 1.72 and 0.73 - 4.04, respectively. The OR and 95% CI of APLA, ACA and central RVO were 4.80 and 2.59 - 8.88, 6.02 and 2.06 - 17.63, respectively. The OR and 95% CI of APLA, ACA, lupus coagulation inhibitor and branch RVO were 4.22 and 1.67 - 10.63, 3.69 and 1.32 - 10.32, 2.07 and 0.79 - 5.41, respectively. Conclusions APLA may increase the rick of RVO, especially ACA has a prediction function to RVO. It is necessary to screening for APLA in RVO patients.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2013年第2期188-192,共5页
Chinese Journal of Ocular Fundus Diseases
基金
十二五国家科技支撑计划（2012BA108806）
关键词
视网膜静脉闭塞
病因学
抗体
抗磷脂
抗体
抗心脂
狼疮凝固抑制物
Meta分析
Retinal vein occlusion/etiology
Antibodies, antiphospholipid
Antibodies, anticardiolipin
Lupus coagulation inhibitor
Meta-analysis
