摘要
目的:探讨自然月经周期卵泡排卵的特点和影响因素。方法:回顾性分析2009年1月至2010年12月在广东省计划生育专科医院行供精人工授精助孕的1412例妇女共2135个自然周期卵泡监测的资料。结果:排卵时卵泡直径中位数为19.00mm,第2.5～97.5百分位数为17.50～23.50mm。随着女性年龄递增,卵泡直径呈逐渐变小的趋势(P=0.001),但不同月经周期、卵泡所在部位、发生未破裂卵泡黄素化综合征(LUFS)和妊娠等因素下卵泡直径差异无统计学意义(P>0.05)。排卵时间中位数为月经周期第15天,第2.5～97.5百分位数为月经周期第11～24天。月经周期<25天者周期妊娠率低于周期≥25天者,但差异无统计学意义(P=0.144)。LUFS发生率3.47%(74/2135),注射HCG(4.82%)或重组人绒促性素α者(7.78%)LUFS发生率显著高于未用药扳机者(2.78%)(P=0.000)。90.86%(1501/1652)卵泡在尿黄体生成素(LH)峰出现强阳性后才发生排卵。与尿LH峰弱阳性或阳性比较,尿LH峰强阳性时排卵时间后移、周期妊娠率增加(P<0.05)。结论:自然月经周期卵泡排卵多发生在月经周期第11～24天和尿LH峰强阳性后。绝大部分卵泡排卵时直径为17.50～23.50mm,并随着女性年龄递增而卵泡直径逐渐变小。
Objective：To investigate the characteristics of follicle ovulation and related factors in natural menstrual cycle. Methods：Consecutive cases of 1412 patients with 2135 natural cycles of artificial insemina- tion by donor from January,2009 to December,2010 in Guangdong Provincial Family Planning Special Hospi- tal were analyzed retrospectively. Results：The median of follicle diameters during ovulation was 19.00 mm, and the 2.5 th to 97.5 th percentiles were 17.50 -23.50 ram. Follicle diameter significantly decreased with the advancing female age （P =0. 001 ）. However, menstrual cycle length, side of ovulation,incidence of luteinized unruptured follicle syndrome （LUFS） and pregnancy did not affect follicle size （ P 〉 0.05）. The median of o- vulation time was Day 15th ,and the 2.5th to 97.5th percentiles were Day 11 th-24th. Cycle pregnancy rate of patients with menstrual cycle length shorter than 25 days was lower than that of those with menstrual cycle length longer than 25 days, but the differences were not significant （P = 0. 144）. The total incidence rate of LUFS was 3. 47% （74/2135）. The incidence rate of LUFS by injection of HCG （4.82%） or recombinant hu- man chorionic gonadotropin alfa （7.78%） were significantly higher than those without injection for triggering （2.78%） （P =0. 000）. 90.86% （1501/1652）follicles ovulated after strongly positive urine luteinizing hor- mone （LH） peak. Compared with weakly positive or positive urine LH peak, ovulation significantly delayed and cycle pregnancy rate significantly increased in patients with strongly positive urine LH peak （P 〈0.05）. Conclusions： In natural menstrual cycles,follicles mostly ovulate on Day 11 th to Day 24 th of menstrual cycle and after strongly positive urine LH peak. The majorities of follicle diameters during ovulation are 17. 5023. 50mm,which significantly decrease with the advancing female age.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2013年第4期282-286,共5页
Journal of Practical Obstetrics and Gynecology
关键词
自然周期
卵泡监测
排卵
未破裂卵泡黄素化综合征
Natural menstrual cycle
Follicle monitoring
Ovulation
Luteinized unruptured follicle syn-drome
