摘要
目的探讨远端胃癌根治术后复发的危险因素,为术后综合治疗及判断预后提供依据。方法回顾性分析实施远端胃癌根治术,且术后病理诊断证实为胃腺癌的195例患者的临床病理资料,以复发时间2年为界划分为复发组和对照组。通过单因素和多因素分析对15项潜在的可能影响远端胃癌根治术后复发的临床病理因素进行统计学分析。结果全组有124例在2年内复发,复发率为63.59%。单因素分析结果示:两组之间术前血红蛋白计数、肿瘤最大直径、肿瘤浸润深度、Borrmann分型、淋巴结转移、淋巴结转移度、肿瘤组织P53蛋白表达、术中腹腔温热化疗的差异有统计学意义(P<0.05)。多因素分析结果示:肿瘤最大直径、淋巴结转移度、肿瘤组织P53蛋白表达、术中腹腔温热化疗是有统计学意义的因素(P<0.05)。结论远端胃癌根治术后复发取决于多种因素的共同作用,肿瘤最大直径、淋巴结转移度、肿瘤组织P53蛋白表达是远端胃癌根治术后复发的独立危险因素,而术中腹腔温热化疗是保护性因素。
Objective To explore the risk factors influencing recurrence of distal gastric cancer after radical resection and to provide the reference for clinic comprehensive therapy. Methods The clinical and pathologic data of 195 patients who underwent distal gastric cancer confirmed by pathological diagnosis after radical resection was retrospectively analyzed in the affiliated hospital of Xiangnan University from January 2004 to december 2010. Ac- cording to postoperative recurrence time the patients were divided into two group. Fifteen potential clinicopatholo- gical factors influencing distal gastric cancer after radical resection recurrence were assessed by univariate and multivariate analysis. Results 124 cases of patients （63.59%） underwent recurrence within two years after radical resection. Univariate analysis showed that the differences of preoperative hemoglobin count, maximum tumor diam- eter, depth of tumor invasion, Borrmann type, lymphnede metastasis （ P = 0.004）, metastatic lymphnode ratio, tu- mor tissue P53 protein expressionand intraoperative peritoneal hyperthermic chemotherapy between two groups had statistical difference（ P 〈 0.05 ）. Multivariate analysis indicated that maximum tumor diameter, metastatic lym- phnede ratio, tumor tissue p53 protein expression,intraoperative peritoneal hyperthermic chemotherapywere factors had significant difference（ P 〈 0.05）. Conclusions The independent risk factors influencing distal gastric cancer after radical resection recurrence include maximum tumor diameter, metastatic lymphnode ratio, tumor tissue P53 protein expression. Intraoperative peritoneal hyperthermic chemotherapy maybe a protective factor.
出处
《湘南学院学报（医学版）》
2013年第1期17-21,共5页
Journal of Xiangnan University（Medical Sciences）
关键词
胃肿瘤
远端
复发
危险因素
多因素分析
Stomach neoplasms
Distal
Recurrence
Risk factor
Multivariate analysis
