摘要
目的:探讨血清肝纤维化与肝功能指标联合检测在肝硬化患者中应用的价值。方法:随机抽取46例肝硬化患者,其中23例为肝硬化静止期,23例为肝硬化活动期。采用化学发光法检测肝纤维化血清标志物透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原N端肽(PⅢNP)和Ⅳ型胶原(CⅣ),同时检测丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)。结果:肝硬化活动期患者血清HA和LN均明显高于肝硬化静止期患者(P<0.01),血清PⅢNP和CⅣ在2组间差异均无统计学意义(P>0.05);血清HA、LN、PⅢNP及CⅣ与ALT、AST均呈正相关关系(P<0.05～P<0.01)。结论:血清HA、LN、PⅢNP及CⅣ可以作为反映肝纤维化程度的指标之一,动态监测其变化很重要。血清肝纤维化指标在肝硬化静止期较活动期明显下降。肝纤维化指标联合肝功能检测有利于临床对疾病演变的监测和治疗。
Objective：To explore the value of liver fibrosis serum markers and liver function in the patients with liver cirrhosis.Methods：Twenty-three patients with liver cirrhosis in the resting stage and 23 patients with liver cirrhosis in the active stage were investigated.The hyaluronic acid（HA）,laminin（LN）,procollagen Ⅲ N-terminal peptide（PⅢNP） and collagen type Ⅳ（CⅣ） of liver fibrosis serum markers of all cases were determined by Chemiluminescence method and the levels of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） were detected.Results：The levels of serum HA and LN of the cases with liver cirrhosis in the active stage were markedly higher than that of the cases with liver cirrhosis in the resting stage（P0.05）,while the serum levels of PⅢNP and CⅣ of two groups had no significant difference（P0.05）.Between the levels of HA,LN,PⅢNP and CⅣ and ALT and AST existed the positive correlation（P0.01 to P0.05）.Conclusions：The serum levels of HA,LN,PⅢNP and CⅣ can reflect the degree of liver fibrosis,which change is very important.The serological indexes of liver fibrosis in the liver cirrhosis in the resting stage is obviously lower than that in the active stage.The detection of the serological indexes of hepatic fibrosis combined with liver function can help to monitor the evolution of the disease and treatment.
出处
《蚌埠医学院学报》
CAS
2013年第3期268-269,272,共3页
Journal of Bengbu Medical College
关键词
肝硬化
透明质酸
层粘连蛋白
Ⅲ型前胶原N端肽
Ⅳ型胶原
肝功能
liver cirrhosis
hyaluronic acid
laminin
Ⅲ before the collagen type N peptides
Ⅳ collagen type
liver function
