摘要
目的:观察特效三消汤加减治疗2型糖尿病的临床疗效及对炎性因子的影响。方法:116例2型糖尿病患者其随机分为对照组和观察组各58例。两组均给予常规基础治疗及二甲双胍,0.5 g/次,口服,2次/d。观察组在此基础上加服特效三消汤加减,1剂/d。两组疗程均为8周。观察空腹血糖(FBG)、餐后2 h血糖(2hBG)及糖化血红蛋白(HbA1c)和肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)及C反应蛋白(CRP)。结果:观察组FBG、PBG、HbA1c及胰岛素敏感指数(ISI)改善情优于对照组(P<0.05或P<0.01);观察组BMI及体质量低于对照组(P<0.05);观察组血糖控制疗效优于对照组(P<0.05);观察组低血糖发生率低于对照组(P<0.01);观察组TNF-α、IL-6及CRP低于对照组(P<0.01)。结论:特效三消汤加减治疗2型糖尿病临床疗效显著,有减轻糖尿病炎性反应的作用,不良反应少,值得在临床广泛推广。
Objective：To investigate the clinical efficacies of the special effect San Xiao decoction on type 2 diabetes mellitus and its impact on inflammatory factors.Methods：116 patients with type 2 diabetes mellitus were randomly divided into control group and observation group from Aug.2010 to Aug.2012,and each group had 58 cases.Both of the two groups were given the conventional basic treatment and 0.5 g/time,oral,2 times/d of metformin.The observation group was received 1 dose/d of special effect San Xiao decoction on the basis of the basic treatment,and the treatment course was 12 weeks.The fasting blood glucose（FBG）,2h postprandial blood glucose（PBG）,glycosylated hemoglobin（HbAlc）,tumor necrosis factor-a（TNF-a）,interleukin-6（IL-6） and c-reactive protein（CRP） were observed after the treatment.Results：The FBG,PBG,HbAlc and insulin sensitive index（ISI） of the observation group were better than those of the control group（P0.05 or P0.01）;BMI and body weight of the observation group were lower than those of the control group（P0.05）;The blood sugar control effect of the observation group was better than that of the control group（P0.05）;The hypoglycemia incidence of the observation group was lower than that of the control group（P0.01）;TNF-a,IL-6 and CRP of the observation group were lower than those of the control group（P0.01）.Conclusion：The clinical efficacy of the special effect San Xiao decoction on type 2 diabetes mellitus is significant,it has the role of alleviating inflammatory response for diabetes and it also has less adverse reactions,which is worth to be applied in clinical.
出处
《中药材》
CAS
CSCD
北大核心
2013年第1期163-166,共4页
Journal of Chinese Medicinal Materials
基金
河南省社科联基金项目(SKL-2010-298)
关键词
2型糖尿病
特效三消汤
肿瘤坏死因子-Α
白介素6
C反应蛋白
Type 2 diabetes mellitus Smellitus
Special effect San Xiao decoction
Tumor necrosis factor-a
Interleukin-6
C-reactive protein
