摘要
目的探讨糖尿病肾病（DN）发病的相关因素。方法选取2009-2011年天津市第四中心医院住院治疗756例2型糖尿病患者，按尿微量白蛋白排泄率（UAER）分为三组，即〈20μg／min为无DN组（A组），20μg／min〈UAER〈200μg／min为微量DN组（B组），≥200gg／min为大量DN组（c组）。记录患者的一般资料，检测实验室指标，用多因素logistic回归分析DN的相关因素。结果756例2型糖尿病患者中DN患者（B组和C组）228例，患病率为30．2％。DN患者年龄、病程、DBP和SBP均显著高于无DN组（A组）（P〈0．05）；大量DN组（c组）年龄、病程、DBP和SBP分别为（64．08±11．71）岁、（14．67±7.34）年、（87．43±14．36）mmHg、（152．45±18．48）mmHg，与微量DN组（B组）对比，差异均有统计学意义（P〈0．05）；B组空腹血糖（FPG）、TG、TC、HDL-C、尿酸（UA）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、空腹C肽（FCP）分别为（9．27±3．06）mmol／L、（1．98±0．37）mmol／L、（5．01±1．08）mmol／L、（1．05±0．35）mmol／L、（312．78±39．83）mmol／L、（9．33±1．47）％、（11．45±7．83）gU／ml、（509．73±132．78）pmol／L，与A组对比，差异均有统计学意义（P〈0．05）；大量DN组（C组）FPG、TG、HDL—C、UA、FINS、FCP分别为（9．29±3．12）mmol／L、（2．02±0．36）mmol／L、（1．04±0．27）mmol／L、（389．72±46．32）mmol／L、（11．09±8．29）gU／ml、（575．77±143．29）pmol／L，与A组对比，差异均有统计学意义（P〈0．05）；大量DN组（C组）与微量DN组（B组）对比，UA、FINS、FCP的差异均有统计学意义（P〈0．05）。多因素logistic回归分析表明，病程、BMI、SBP、HbA1c、FPG、UA与DN的发生有关。结论DN的发生与病程、年龄及血糖、血脂、血压、尿酸水平密切相关。
Objective To analyze the related factors regarding diabetic nephropathy （DN）. Methods A total number of 756 diabetic patients from 2009 to 2011 were analyzed retrospectively. Three groups were formed according to the urinary albumin excretion rates （UAER）. Patients with UAER〈20 μg/min was grouped to group A, with UAER from 20 to 200 μg/min as group B, and the others with UAER ≥200 μg/min was grouped to group C. General characteristics and laboratory parameters were then compared and related factors of DN analyzed. Results The constituent ratio of nephropathy was 30.2% （228/756）. Patient＇ s age, duration of disease, both diastolic and systolic blood pressure of group A were significantly higher than the non-DN group （A） （P〈0.05）. Patient＇ s age, disease duration, both diastolic and systolic blood pressure of group C were （64.08 ± 11.71 ）years, （ 14.67± 7.34） years, （87.43±14.36） mm Hg, （ 152.45 ±18.48） mm Hg, respectively, with statistically significant difference （P〈0.05） between group C and group B. FPG, TG, TC, HDL-C, UA, HbAlc, FINS, FCP of group B were （9.27 ±3.06）mmol/L, （1.98 ± 0.37）mmol/L, （5.01 ± 1.08）mmol/L, （ 1.05 ±0.35 ）mmol/L, （312.78 ±39.83）mmol/L, （9.33 ±1.47）%, （ 11.45 ± 7.83） μU/ml, （509.73 ±132.78） pmol/L respectively, with significant difference （P〈0.05） between group B and group A. FPG, TG, HDL-C, UA, FINS, FCP of group C were （9.29± 3.12）mmol/L, （2.02 ±0.36）mmol/L, （1.04 ± 0.27）mmol/L, （389.72±46.32）mmol/L, （11.09 ± 8.29） μU/ml, （575.77 ± 143.29）pmol/L respectively, with significant difference （P〈0.05） between group C and group A. UA, F/NS, FCP were found with significant differences （P〈0.05） between group C and group B. Data from multivariate logistic regression showed that DNs were related with disease duration, BMI, systolic blood pressure, HbAlc, FPG, UA. Conclusion DN was closely related to the duration, age, blood sugar, blood lipids, blood pressure, uric acid levels of the disease.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2013年第4期393-395,共3页
Chinese Journal of Epidemiology
关键词
糖尿病肾病
相关因素
高尿酸
Diabetic nephropathy
Relevant factors
Hyperuricemia
