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左卡尼汀对急性冠脉综合征患者PCI围术期心肌梗死的预防作用 被引量：10

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摘要 目的观察左卡尼汀对急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)围术期心肌梗死的预防作用。方法 510例拟行PCI的ACS患者在常规治疗的基础上随机分为治疗组和对照组,各255例。治疗组患者入院后给予左卡尼汀3.0 g加入0.9%氯化钠注射液250 mL持续静滴,对照组给予0.9%氯化钠注射液静滴,均1次/d,连用7～10 d;两组均于入院后第2天进行PCI。所有患者分别于PCI术前和术后8、24 h及3、7 d抽取外周静脉血检测血清肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、高敏C-反应蛋白(hs-CRP)、氮末端脑钠肽原(NT-proBNP),并同时做18导联心电图。结果 PCI围术期共发生心肌梗死105例,其中治疗组38例(14.9%),对照组67例(26.27%),两组相比,P<0.01。两组血清CK-MB、cTnT、hs-CRP、NT-proBNP水平在PCI后均升高(P均<0.05),尤以对照组升高明显;CK-MB≥5倍正常值上限和cTnT≥10倍正常值上限者,治疗组4例(4/38,10.53%)、对照组26例(26/67,38.81%),两组相比,P<0.01;PCI术后TIMI 3级血流在治疗组和对照组分别为241例(94.51%)和159例(62.35%),两组相比,P<0.01。结论 ACS患者PCI围术期应用左卡尼汀对缺血损伤的心肌有保护作用,可降低围术期心肌梗死的发生率。
作者 殷宪刚 高晓燕 李瑶
机构地区 山东大学附属省立医院 济南市天桥人民医院 济南军区总医院
出处 《山东医药》 CAS 2013年第15期53-55,共3页 Shandong Medical Journal
关键词 左卡尼汀 急性冠脉综合征 心肌梗死 经皮冠状动脉介入治疗
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

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共引文献43

同被引文献92

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引证文献10

二级引证文献26

山东医药
2013年 第15期

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