摘要
目的采用补肾活血法干预老年单纯收缩期高血压患者，观察其对24h微量白蛋白（Malb）、视黄醇结合蛋白（RBP）水平的影响。方法采用随机数字表法将90例老年单纯收缩期高血压患者随机分为两组。治疗组52例口服补肾活血汤治疗，其中脱落1例，51例进入统计：对照组38例口服安慰剂，其中脱落2例，36例进入统计。比较两组患者治疗前，治疗后2、4、8周血压及治疗前后Malb、RBP水平的变化。结果①血压：治疗组收缩压治疗后4、8周[分别为（144．03±12．33）rfll／lHg（1mmHg=0．133kPa）、（132．27±13．15）mmHg]较同组治疗前[（156．32±12．05）rnlnHg]明显改善（P〈0．05），与对照组治疗后第4、8周[分别为（151．19±13．83）mmHg、（152．74±12．03）mmHg]比较，差异有统计学意义（P〈0．05）。②Malb、RBP水平：治疗后治疗组Malb、RBP水平[分别为（40．80±13．51）mg／L、（150．43±23．62）mg／L]均较同组治疗前[分别为（50．14±15．61）mg／L、（220．04±30．20）mg／L]改善（P均〈O．05），与对照组治疗后[分别为（52．12±14．69）mg／L、（219．34±34．37）mg／L]比较，差异均有统计学意义（P均〈0．05）。结论补肾活血法可改善肾脏功能，并可能通过改善肾功能降低收缩压。
Objective Kidney-supplementing and blood-activating method was adopted in treating senile patients with isolated systolic hypertension to observe its decompression effects and influences on microalbunminuria （Malb）, retinol binding protein （RBP） level in 24 hours. Methods 90 patients with simple systolic hypertension were randomly recurited into two groups. 52 cases in the treatment group were administered with kidney-supplementing and blood-activating decoction, including 1 case failing off and 51 cases entering statistical analysis; 38 cases in the control group were administered with oral placebo, among them 2 cases were fallen offand 36 cases were entered statistical analysis. Both groups were treated for 8 weeks. Results ① Blood pressure： systolic blood pressure at 4 and 8 weeks after the treatment in the treatment group [ （144.03 ± 12.33）mm Hg （ 1 mm Hg = 0.133 kPa） and （132.27±13.15）mm Hg] was significantly improved than before the treatment [ （156.32± 12.05）mm Hg] （P〈0.05）, and also significantly better than the control group at 4, 8 weeks after the treatment [（151.19±13.83）mm Hg, （152.74±12.03）mm Hg] （P〈0.05）. ② The Malb, RBP level： Malb, RBP level [ （40.80± 13.51） mg/L, （150.43 ±23.62）mg/L] after the treatment in the treatment group was reduced than before the treatment [ （50.14± 15.61） mg/L, （220.04±30.20）mg/L] （19〈 0.05）, and was significantly different to the control group after treatment [ （52.12± 14.69）rag/L, （219.34± 34.37）mg/L] （P〈0.05）. Conclusion Kidney-supplementing and blood-activating method can improve kidney function, and thus to reduce the effect of systolic blood pressure.
出处
《国际中医中药杂志》
2013年第4期313-315,共3页
International Journal of Traditional Chinese Medicine
