摘要
以联合国粮农组织和世界卫生组织食品添加剂联席专家委员会(JECFA)第67次会议对食品中铝暴露的风险评估报告为主要依据,分析了铝的毒性,给出了铝及其铝化合物毒性的综合评价。指出JECFA推荐铝的健康指导值为人体每千克体质量每周可容许摄入量为1.0mg/kg。由于不同形态铝的毒性相差甚远,因此测定总铝意义不大。特别是对于水产品及其制品,铝主要以稳定的、不易被生物体吸收的有机铝形态存在,而毒性较高的无机可溶态铝占总铝的百分比<5%。因此,分析铝在食物中的具体形态,对探讨铝的毒理学行为、生物利用率及其食用安全性评价具有十分重要的意义。
This paper was to evaluate the health risk of A1 from dietary exposure based on the evaluation report at the thirty - third JECFA meeting. The health risk evaluation findings in the past JECFA reports were compared. The tox- icity of aluminum was analyzed and a comprehensive evaluation on the toxicity of A1 and other aluminum compounds were discussed. In addition, the committee set a provisional tolerable weekly intake （PTWI） of 1.0 mg/kg body weight for aluminum, including food additive usage. Different A1 speciations have different toxicity, so only analyzing total A1 is not enough for the risk assessment. Especially for seafood, our experiments have proved that most A1 speci- ation is the organic A1 compounds which are not easily absorbed by biology, while the inorganic A1 which is most toxic for the biology occupied less than 5% of the total A1 content. It is suggested that A1 speciation analysis is very impor- tant for the toxic evaluation, bioavailability and risk assessment of A1 in the food.
出处
《中国渔业质量与标准》
2013年第1期6-13,共8页
Chinese Fishery Quality and Standards
基金
农产品质量安全监管专项经费(2011)
中华人民共和国农业行业标(2011-13516)
国家"十二五"支撑课题子课题(2011BAD13B06)
中国水产科学研究院院本级基本科研业务费(2012C007)
