摘要
通过原位聚合法制备新型生物活性羟基磷灰石/二元氨基酸共聚物(BHA/PAA)复合材料。采用1 H核磁共振(1 H NMR)、红外光谱(IR)、X-ray衍射光谱(XRD)、X射线光电子能谱(XPS)、扫描电镜(SEM)和差示扫描量热分析(DSC)对其组成结构、热性能、力学性能和体外降解性能进行研究。结果表明:BHA颗粒均匀分散在PAA基质中,形成的复合材料具有良好的均一性;复合材料的无机相和有机相之间存在着一定的化学键相互作用;由于BHA的引入,复合材料的结晶速率加快,整体结晶度下降;复合材料具有良好的力学性能,其抗压强度随着BHA含量的增加而明显提高,抗弯强度略有减小,当BHA含量为30%(质量分数)时,复合材料的抗压强度和抗弯强度分别为141.02MPa和86.32MPa,力学性能与人体皮质骨相匹配;体外降解实验结果表明,随着BHA含量的增加,材料的降解速率加快,且在降解过程中保持良好的力学性能稳定性,在骨修复方面具有潜在的应用。
A novel synthetic materials of bio-hydroxyapatite/poly（amino acid） copolymer composite for bone repair was prepared by in-situ polymerization. The structure and thermal properties were charac- terized by nuclear magnetic resonance （1HNMR）, infrared spectrometer （IR）, X-ray diffractmeter （XRD）, X-ray photoelectron spectroscopy （XPS）, scanning electron microscope （SEM） and differen- tial scanning calorimeter （DSC）~ the compressive and flexural strength of the composite containing different BHA contents were investigated during degradability. The results indicated that the BHA particles distributed uniformly in the composite. The IR and XPS results showed that chemical bond was present between inorganic （BHA） and the organic （PAA）. With 30~ （mass fraction）BHA, the compressive strength of the composite enhanced with the introduction of BHA and reached 141.02MPa, and flexural strength was 86.32MPa, which is in the range of natural bone mechanical strength. The composite exhibited excellent degradability and its degradability enhanced with the in- creased of BHA content, and exhibited good biomechanical strength.
出处
《材料工程》
EI
CAS
CSCD
北大核心
2013年第4期56-62,共7页
Journal of Materials Engineering
