期刊文献+

褪黑素能类药物研究进展 被引量:15

Melatonergic drugs: research advances
下载PDF
导出
摘要 褪黑激素(美乐托宁)是一种专司调节生物节律的神经激素,具有调节免疫系统、抑制肿瘤细胞增殖、保护胃肠道、抗脑损伤和痛觉调制等多种生理作用。褪黑激素主要通过介导两个G蛋白偶联受体MT1和MT2而发挥作用。由于其半衰期短、临床应用受限,多种褪黑激素衍生物和类似物被研究,以获得活性高、药代动力学性质良好的药物。本文主要介绍已上市和处于临床试验的褪黑素能类药物的研究概况。 Melatonin is a hormone responsible for regulating biological rhythms. It has multiple physiological actions such as immune regulation, inhibition of tumor, gastrointestinal tract protection, brain injury prevention and pain regulation, and exerts its ac- tions mainly through two G-protein-coupled receptors MT1 and MT2. To overcome its shortcomings of short half-life and limited clinical application, a variety of melatonin derivatives and analogues have been developed in order to get compounds with high activity and good pharmacokinetic properties. Recent advances in melatonergic drugs which have been listed or in clinical trials are summarized in this review.
出处 《国际药学研究杂志》 CAS CSCD 2013年第2期162-166,共5页 Journal of International Pharmaceutical Research
基金 国家自然科学基金项目(81072613) 十二五国家科技重大专项"重大新药创制"综合性新药研究开发技术大平台项目(2012ZX09301003-001-010)
关键词 褪黑激素 褪黑激素受体 雷美替胺 阿戈美拉汀 他美替胺 PD-6735 吡罗美拉汀 melatonin melatonin receptors ramelteon agomelatine tasimeheon PD-6735 piromelatine
  • 相关文献

参考文献1

二级参考文献63

  • 1Wong ML, LicinioJ. Research and treatment approaches to depression. Nat Rev Neurosci 2001; 2: 343-51.
  • 2Greenberg PE, Kessler RC, Birnbaum HG, Leong SA, Lowe SW, Berglund PA, et el. The economic burden of depression in the United States: how did it change between 1990 and 2000? J Clin Psychiatry. 2003; 64: 1465-75.
  • 3Murphy SL. Deaths: final data for 1998. Natl Vital Stat Rep 2000; 48: 1-106.
  • 4Harris EC, Barraclough B. Excess mortality of mental disorder. Br J Psychiatry 1998; 173: 11-53.
  • 5Glassman AH, Shapiro PA. Depression and the course of coronary artery disease. Am J Psychiatry 1998; 155: 4-11.
  • 6Lenox RH, Frazer A. Mechanism of action of antidepressants and mood stabilizers. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: the fifth generation of progress. Philadelphia: Williams & Wilkins; 2002. p 1139-63.
  • 7Nash J, Nutt D. Antidepressants. Psychiatry 2007; 6: 289-94.
  • 8Hudson JL, Gradisar M, Gamble A, Schniering CA, Rebelo I. The sleep patterns and problems of clinically anxious children. Behav Res Ther 2009; 47: 339-44.
  • 9Srinivasan V, Pandi-Perumal SR, Trakht I, Spence DW, Hardeland R, Poe-eler B, et al. Pathophysiology of depression: role of sleep and the melatonergic system. Psychiat Res 2009; 165: 201-14.
  • 10Takeuchi T, Nakao M, Nomura K, Yano E. Association of metabolic syndrome with depression and anxiety in Japanese men. Diabetes Metab 2009; 35: 32-6.

共引文献10

同被引文献190

引证文献15

二级引证文献209

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部