摘要
目的探讨重型颅脑损伤患者行腰穿及腰大池引流时脑脊液中肌酸激酶脑型同工酶(CK-BB)及乳酸脱氢酶(LDH)的变化,以及检测两者脑脊液中CK-BB及LDH变化速度。方法将100例入选患者分为单纯腰穿组与腰大池引流组,每组50例,分析脑脊液中CK-BB及LDH在第3、5、7 d的变化情况。结果腰穿外引流组CK-BB和LDH浓度在检测的时间内,CK-BB平均下降速度快64.2%、LDH平均下降速度快54.83%,差异有统计学意义(P<0.05);GCS评分及良好率高于腰穿组,但差异无统计学意义(P>0.05),致残率和死亡率差异无统计学意义(P>0.05)。结论腰大池外引流在治疗重型颅脑损伤患者能明显缩短疗程,减少住院费用,改善预后,降低致残率和死亡率。
To investigate CK - BB and LDH changes in cerebrospinal fluid of patients with severe traumatic braininjury through lumbar puncture and lumbar cistern drainage and change velocity contrast clinical significance both CK - BB and LDH de-tection in cerebrospinal fluid. Methods 100 patients were randomly divided into simple spinal puncture group （ n = 50） and into lumbar cistern drainage group （n = 50）, between Sep. 2010 and Aug. 2012, change situation of CK-BB and LDH in eerebrospinal fluid were analyzed among the third days, the fifth days and the seventh days. Results The lumbar puncture drainage group CK -BB and LDH concentration in the test time, average dropping speed of CK - BB （64.2%） and LDH （54.83%） was faster （ P 〈 0.05 ）. GCS score and good rate was higher than lumbar puncture group and had certain differences, but there was no statistically significant （ P 〉 0.05 ）. Morbidity and mortality was lower than lumbar puncture group, no statistical significance （ P 〉 0.05 ）. Conehmion In the process of treating severe brain injury patients, lumbar cistern drainage can shorten the course of treatment and reduce the patients＇ hospitalization expenses and improve prognosis and reduce the rate of disability and mortality.
出处
《宁夏医学杂志》
CAS
2013年第4期291-293,共3页
Ningxia Medical Journal
基金
宁夏医科大学项目科研资助项目(XM201032)
