摘要
目的评价乌司他丁、丹参联合用药对重症急性胰腺炎(SAP)时血清肿瘤坏死因子-a(TNF-a)、白细胞介素-10(IL-10)的影响,从而了解乌司他丁、丹参联合用药对SAP的临床疗效。方法将68例SAP患者随机分为治疗组(34例)和对照组(34例),对照组仅采用西医综合治疗,治疗组在西医综合治疗基础上加用乌司他丁及丹参注射液。检测治疗前及治疗后1、3、6、10d两组血清TNF-α、IL-10水平,并观察两组的治疗有效率;白细胞、血淀粉酶恢复时间;腹痛缓解时间及平均住院时间。结果治疗后两组白细胞、血淀粉酶、腹痛缓解时间及平均住院时间四项指标均有所恢复,但是治疗组恢复时间较对照组明显缩短(P<0.01)。两组TNF-α水平较治疗前明显下降(P<0.01);IL-10水平较治疗前明显增高,而治疗组较对照组变化更明显(P<0.01)。结论应用乌司他丁、丹参治疗急性胰腺炎,能抑制TNF-α分泌,上调IL-IO水平,对SAP具有良好的治疗作用。
Objective To investigate the effect of ulinastatin and salvia miltiorrhiza on the serum levels of tumor necrosis factor-a（TNF-α） ,interleukin-10（IL-10） of patients with severe acute pancreatitis（SAP）, and to study the clinical efficacy of ulinastatin combination with salvia of patients with SAP. Methods 68 patients with SAP were randomly divided into treatment group（ 34 ca-ses） and control group（ 34 cases）, the control group using only comprehensive treatment of western medicine, traditional Chinese medicine and western medicine therapy in the treatment group based on the use ulinastatin and salvia miltiorrhiza injection. Test be fore treatment and after treatment 1,3,6,10 d, serum TNF-α, IL-10 levels and the efficiency of treatment were observed; white blood cells,blood amylase recovery time,pain relief time and the average length of stay. Results After treatment, the white blood cells, serum amylase, abdominal pain, ease the time and the average length of stay by four parameters were restored, but the recovery time in patients treated with even more significant, than the control group was significantly shorter（P^0.01）. Compared to before treated,in both of the two groups,the levels of serum TNF-a decreased significdntly（P〈0.01）. IL-10 increased significantly after treating,but changes of treated group were more significant（P（0.01）. Conclusion Application ulinastatin combination with salvia miltiorrhiza treatment of acute pancreatitis can decreases serum levels of TNF-α and increases IL-1, and have favorable treatment elect on patient with SAP.
出处
《国际检验医学杂志》
CAS
2013年第8期962-963,965,共3页
International Journal of Laboratory Medicine
