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成骨细胞在造血微环境中的作用

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摘要 造血干细胞（HSC）具有自我更新能力并且能够发育成各系血细胞。这一过程只有在特定的骨髓微环境中才能完成,早在1978年Sehofield[1]就提出龛的概念来定义骨髓中适宜HSC生存的特定微环境结构。该假说认为HSC定位于骨髓特定的三维环境内,以维持其自我更新的特点,而一旦离开龛,HSC在基质细胞和各种细胞因子作用下进入增殖和分化状态,分化发育为各种成熟血细胞。
作者 郝润英 张书霞 贺冠强 王菊美
机构地区 河北省邯郸市中心医院检验科 河北省邯郸市中心医院血液科
出处 《国际检验医学杂志》 CAS 2013年第8期996-998,共3页 International Journal of Laboratory Medicine
关键词 造血干细胞 造血微环境 成骨细胞
分类号 R363 [医药卫生—病理学]
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参考文献22

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二级参考文献17

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国际检验医学杂志
2013年 第8期

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