摘要
目的探讨脂联素水平与我国青少年代谢综合征及相关心血管疾病危险因素之间的关系。方法分层整群抽取辽阳市初中和高中青少年学生933人,进行体格检查,测定各项生化指标,酶联免疫法(ELISA)检测脂联素,评估脂联素水平与代谢综合征及各心血管疾病相关危险因素之间的关系;907人统计资料完整(11～16岁,男性53.3%)。代谢综合征依据2007年国际糖尿病联盟(IDF)制定的儿童青少年标准。结果脂联素与腰围、体质指数、舒张压、甘油三酯、糖化血红蛋白、空腹血清胰岛素等多种代谢性指标及稳态模型胰岛素抵抗指数(HOMA-IR)之间呈显著负相关(P<0.05);校正全部影响因素后,脂联素水平下降仍是代谢综合征患病的独立危险因素(OR=5.83,95%CI 1.98～17.18);与脂联素水平下降关系最密切的代谢综合征组份为中心型肥胖(OR=3.48,95%CI 1.84～6.59)和高密度脂蛋白胆固醇降低(HDLC,OR=1.57,95%CI 1.09～2.26)。结论脂联素水平是青少年代谢综合征的独立危险因素,与心血管疾病危险因素存在相关关系。
Aim To examine the association of adiponectin with metabolic syndrome （MS） and related cardio- vascular disease （CVD） risk factors in Chinese adolescents. Methods This was a cross-sectional study including 933 adolescents. All participants underwent anthropometric and biochemical examinations. Adiponectin was measured using ELISA. The association of adiponectin with CVD risk factors and the presence of metabolic syndrome were evaluated. MS was defined with the International diabetes federation （IDF） 2007 definition specific for children and adolescents. Of the 933 subjects, the data of 907 ones were complete and entered the statistic analysis. Results With the reducing adiponectin, waist circumference （WC）, body mass index （ BMI）, triglyceride （TG）, hemoglobin A1 c （ HbA1 c）, fasting plasma insulin （FINS） and the homeostasis assessment model of insulin resistance （HOMA-IR） were increased （all P 〈 0. 05）. Adiponectin was significantly correlated with WC, BMI, diastolic blood pressure （DBP）, TG, total cholesterol （TC） and HbA1 c （ all P 〈 0. 05 ）. Adiponectin showed independent association with MS （ OR = 5.83,95% CI 1.98- 17. 18 ） and the most closely correlated component was central obesity （ OR = 3. 48,95% CI 1.84 - 6. 59 ） and lower high density lipoprotein cholesterol （HDLC, OR = 1.57,95% CI 1.09 - 2. 26）. Conclusions Adiponectin was independ- ently associated with the presence of MS and related multiple CVD risk factors in Chinese adolescents.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2013年第4期349-353,共5页
Chinese Journal of Arteriosclerosis
基金
辽宁省科学技术计划项目(2008225009-21)
关键词
脂联素
代谢综合征
心血管疾病
危险因素
青少年
Adiponectin
Metabolic Syndrome
Cardiovascular Disease
Risk Factor
Adolescent
