摘要
目的:观察中药复方胶囊对脑缺血再灌注所致血管性痴呆(VD)小鼠学习记忆的影响。方法:采用双侧颈总动脉反复夹闭同时尾尖放血法造成小鼠血管性痴呆模型,以跳台法和Morris水迷宫法评价VD模型小鼠学习记忆功能的影响。结果:VD模型小鼠学习记忆能力降低,表现为反应时间延长,记忆潜伏期缩短,错误次数增加,逃避潜伏期和逃避路程延长;中药复方胶囊能使VD小鼠反应时间缩短,记忆潜伏期延长,错误次数减少,逃避潜伏期和逃避路程缩短。结论:中药复方胶囊能显著改善脑缺血再灌注所致血管性痴呆小鼠的学习记忆能力,对血管性痴呆具有一定的保护作用。
Objective To investigate the effcets of Chinese herbal compound caspsule on learning - memory function in vascular deme- tia mice.Methods Vascular demetia（VD） mice model was made by two times of transient ischemia and reperfusion of bilateral common ca- rotid arterises plus tail end depletion.Use the methods of morris water maze and jumping stand to test the abilities of learning-merory. Results The ethological experiment showed that the mice learning-memory ability decreased in VD group,compared with the group of sham operation, the response period of model group was prolonged ,the memory latent period was shortened ,the number of error was in- creased,the escaping latent period and escaping distant was prolonged.The Chinese herbal conmpound caspsule could shortened the re- sponse period ,prolonged the memory latent period,decreased the error number, shortened the escaping latent period and escaping distant in VD mice. Conclusion The Chinese herbal conmpound caspsule can significantly improve the learning-memory function in VD mice and have a protective effect on VD.
出处
《江西中医学院学报》
2012年第5期46-48,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
基金
国家科技重大专项:重大新药创制(项目编号:2011ZX09101-003-02)
关键词
血管性痴呆
中药复方胶囊
学习记忆
小鼠
Vascular Demetia
Chinese Herbal Conmpound Caspsule
Learning-memory
Mice
