摘要
利用两步原子转移自由基聚合(ATRP)方法,初步建立了新型聚合物整体柱固相萃取(SPE)材料制备的新方法。首先利用ATRP方法,以乙二醇二甲基丙烯酸酯(EDMA)为交联剂,在室温条件下,在滤头中原位快速聚合制备得到负载有聚合物整体柱的萃取装置;然后采用表面诱导的电子转移活化再生原子转移自由基聚合(ARGETATRP)方法进行表面修饰,得到了聚(二甲基氨基乙基甲基丙烯酸酯)(PDMAEMA)修饰的柱体;进一步将此整体柱用作萃取材料,实现了对激素类药物的富集分析。本研究表明:ATRP有望作为一种简单、有效及反应条件温和的聚合方法用于整体柱的制备,且该方法有潜力实现固相萃取材料在不同装置中的制备。
In this study,a novel polymer monolith based solid phase extraction（SPE） material has been prepared by two-step atom transfer radical polymerization（ATRP） method.Firstly,employing ethylene glycol dimethacrylate（EDMA） as a cross-linker,a polymer monolith filled in a filter head has been in-situ prepared quickly under mild conditions.Then,the activators generated by electron transfer ATRP（ARGET ATRP） was used for the modification of poly（2-（dimethylamino）ethyl-methacrylate）（PDMAEMA） on the monolithic surface.Finally,this synthesized monolith for SPE was successfully applied in the extraction and enrichment of steroids.The results revealed that ATRP can be developed as a facile and effective method with mild reaction conditions for monolith construction and has the potential for preparing monolith in diverse devices.
出处
《色谱》
CAS
CSCD
北大核心
2013年第4期317-321,共5页
Chinese Journal of Chromatography
基金
国家"973计划"项目(2007CB714504)
国家自然科学基金项目(21175138
20935005)
关键词
原子转移自由基聚合
聚合物整体柱
固相萃取
atom transfer radical polymerization（ATRP）
polymer monolith
solid phase extraction
