摘要
采用复凝聚法,以明胶和海藻酸钠为基质材料制备了啶虫脒缓释微球,以微球的药物包封率和微球外观作为优化制备工艺条件的参考指标,通过L16(45)正交实验得出微球的最佳制备工艺条件:明胶与海藻酸钠的浓度比为2∶1、复凝聚温度为45℃、复凝聚反应所需时间为80min、CaCl2浓度为0.5mol/L、啶虫脒药量为1.0g。利用体外释放实验测试缓释微球的释放特性,结果表明:合成的明胶/海藻酸钠微球对啶虫脒有良好的缓释作用。
A complex coacervation method of the sustained-releasing microspheres containing acetamiprid was developed with gelatin and sodium alginate as base materials. The preparation condition were optimized using L16 （4S ）orthogonal experimental design with the drug encapsula- tion and the shape of the microspheres as criteria. As a result, the optimum preparation condi tions of the microspheres were as follows, the concentration ratio of gelatin to sodium alginate was 2 ： 1, the tempture of the method was 45 ℃, the complex coacervation time was 80 min, the concentration of CaC12 was 0.5 mol/L, the dosage of acetamiprid was 1.0 g. The release profiles of acetamiprid from the beads were investigated in-vitro, and the result proved that the gelatin/sodium alginate microspheres had a good drug releasing performances for acetamiprid.
出处
《河北农业大学学报》
CAS
CSCD
北大核心
2013年第2期90-93,共4页
Journal of Hebei Agricultural University
基金
河北农业大学科研发展基金(Fs201009)
河北省科技支撑计划项目(11220302D)
关键词
啶虫脒
明胶
海藻酸钠
缓释
控释
acetamiprid
gelatin
sodium alginate
delayed release/controlled release
