摘要
为观察补肾泻肝方治疗慢性再生障碍性贫血 (再障 )的疗效 ,并探讨该方对其免疫紊乱与造血的治疗机理。据滋肾助阳治本 ,结合泻肝清火治标的治疗原则 ,用补肾泻肝糖浆治疗再障 60例。结果 :总有效率 88.3 3 % ,治愈缓解率 5 5 % ,其中肾阴虚、肝火伏热型的有效率为 97.14 % ,明显优于肾阳虚、阴亏瘀热型 76% (P <0 .0 5 )。经补肾泻肝方治疗后 ,TS数量降低 ,TH/TS的比例提高 ,sIL -2R、IL-3水平增高 ,IL -2、IFN -γ含量减低。提示该方具有降低TS细胞数量和活性 ,调整T细胞亚群的比值失衡 ,改善细胞因子分泌异常 ,以促进骨髓造血功能恢复的作用。
In the observation of the therapeutic effect of “Kidney-Tonifying and Liver-Sedating Formula”in the treatment of chronic aplastic anemia and in the exploration of its therapeutic mechanism for immune disturbance and hematopoiesis,60 cases of aplastic anemia were treated with “Kidney-Tonifying and Liver-Sedating Syrup”,based upon the principle to treat the causative reason by replenishing the kidney and assisting yang and to treat the symptoms by combination of the method to sedate the liver and clear away heat.The results showed the total effective rate in 88.33% and the cure remission rate in 55%.Among them,the effective rate was 97.14% in the patterns of kidney yin deficiency and of hiding heat of the liver fire and was remarkably better than 76% in the patterns of kidney yang deficiency and of accumulated heat of yin deficiency.After the treatment with “Kidney Tonifying and Liver Sedating Formula”,TS count was lowered and TH/TS ratio was enhanced,with sIL-2R,IL-3 level increased and IL-2 and IFN-γ contents decreased,indicating that this formula possesses the function to lower TS cell count and activity,regulate the ratio imbalance in T cell subgroup and improve the secretory abnormality in cellular factor for promoting restoration of the hematopoietic function in bone marrow.
出处
《上海中医药大学学报》
CAS
2000年第1期20-24,共5页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家中医药管理局基金资助项目!(95B035)
关键词
再生障碍性贫血
补肾泻肝方
细胞因子
Aplastic anemia
“Kidney Tonifying and Liver Sedating Formula”
T cell subgroup
Cytokine
hematopoiesis
