摘要
二甲双胍是治疗2型糖尿病的常用药物。近年来多项流行病学研究显示，二甲双胍可降低肿瘤风险，可减慢肿瘤生长，有望成为一种新的抗肿瘤药物。肺癌是严重危害人类健康的疾病，发病率高，病死率高，预后差。有研究表明口服二甲双胍可延长肺癌患者生存期，改善预后。本文就近年二甲双胍对肺癌的作用及其机制进行综述。
Metformin is commonly used for treating patients with type 2 diabetes mellitus. Recent epidemiologic studies have indicated that metformin may reduce cancer risk, impede the growth of tumor and can be a potential antineoplastic drug. Because of its high morbidity, high mortality, and poor prognosis, lung cancer is a disease which seriously endangers health and lives of people. It has been reported that metformin can improve both the survival rate and the prognosis of lung cancer. This review outlines and analyzes the influence of metformin on lung cancer and its mechanism.
出处
《国际呼吸杂志》
2013年第8期615-618,共4页
International Journal of Respiration
关键词
二甲双胍
肺癌
Metformin
Lung cancer
