摘要
目的研究卒中后抑郁患者血清胰岛素样生长因子-1(IGF-1)与临床病理因素的关系。方法选择脑卒中后抑郁患者为研究对象(PSD组),以同期健康体检的正常人为对照组(CON组),比较两组间IGF-1的差异,比较不同临床病理因素中IGF-1的差异。结果 PSD组患者血清IGF-1水平为(47.7±6.5)ng/mL,CON组血清IGF-1水平为(20.3±3.6)ng/mL,PSD组患者血清IGF-1水平显著高于CON组(P<0.05)。PSD组患者血清IGF-1水平在性别、年龄、吸烟史、糖尿病史、脑卒中部位及脑卒中分布中的差异无统计学意义(均P>0.05),在抑郁程度中的差异有统计学意义(P<0.05),抑郁程度越高,PSD患者血清IGF-1水平越高。结论卒中后抑郁患者血清IGF-1与抑郁程度有关,可作为卒中后抑郁病情评估的标志物。
Objective To study the relationship between insulin-like growth factor-I （IGF-1） and clinicopathological factors in poststroke depression. Methods Poststroke depression patients were selected for study （PSD group）, and healthy normal subjects in the same period were selected as control group （CON group）. The insulin-like growth factor-1 were compared and the relationship between insulin-like growth factor-1 and clinicopathological factors was analyzed. Results The IGF-1 in PSD group was （47.7±6.5）ng/mL while it was （20.3±3.6）ng/mL in CON group. The IGF-1 in PSD group was significantly higher than that in CON group （P 〈 0.05）. The differece of insulin-like growth factor-1 in different degree of depression was significant （P 〈 0.05）, while they were not significantly different in a- gender, age, smoking story, diabetes story, stroke location and distribution. Conclusion The IGF-1 correlates with degree of depression in poststroke depression, which could act as a biomarker for poststroke depression.
出处
《中国当代医药》
2013年第13期26-27,共2页
China Modern Medicine
