摘要
目的观察益生菌联合制霉菌素、鱼肝油治疗婴幼儿鹅口疮的临床疗效及对婴幼儿口腔sIgA水平的影响。方法将47例鹅口疮患儿随机分成对照组(n=22)及治疗组(n=25)例,对照组常规用制霉菌素片加鱼肝油涂抹口腔治疗,治疗组在制霉菌素片及鱼肝油涂抹口腔基础上口服益生菌,连续治疗4周后,观察两组疗效及复发率,同时检测患儿口腔中sIgA分泌量的变化。结果治疗组总有效率为84%,总复发率为8.0%,对照组总有效率为63.6%,总复发率为22.7%,两组总有效率及总复发率比较差异有统计学意义;对照组口腔唾液分泌sIgA量在治疗期间虽有一定程度提高,但始终徘徊在低水平,治疗组在服用4周益生菌后唾液sIgA分泌量有了新的较大提高,且维持较高水平,与对照组相比差异有统计学意义。结论益生菌治疗婴幼儿鹅口疮疗效好,安全性高,复发率低,可有效诱导消化道黏膜免疫应答,提高婴幼儿免疫力,易被广大家长及患儿接受,值得临床推广应用。
Objective To observe the clinical effect of lactobacillus combined with nystatin on infantile thrush and the influence of the sIgA level in saliva.Methods 47 cases of thrush children were randomly divided into the control group(n=22),which were treated with nystatin tablets and cod liver oil,and the treatment group(n=25),which were given the same with the control group and lactobacillus.After four weeks,the efficacy and recurrence rates were compared and the saliva sIgA was tested.Results The total efficiency rate and recurrence rate of the treatment group were 84% and 8.0%,and those of control group were 63.6% and 22.7%(P<0.01).Saliva sIgA level in the treatment group increased to and then maintained at a normal level,which was significantly higher than that in the control group(P<0.01).Conclusion The combination of lactobacillus in treatment of infantile thrush is effective and safe in enhancing the immunity in children by inducing mucous membrane immune response.This therapy is easily acceptable to the parents and worthy of clinical application.
出处
《中国微生态学杂志》
CAS
CSCD
2013年第4期422-424,共3页
Chinese Journal of Microecology
