摘要
目的探讨半乳糖凝集素-3（Gal-3）和糖链抗原242（CA242）蛋白表达与老年胃癌临床病理特征和患者预后的关系。方法应用免疫组化技术检测60例老年胃癌、30例异型增生和20例癌旁正常胃黏膜组织中Gal-3和CA242蛋白表达，并结合肿瘤的病理学行为和临床随访资料进行分析。结果在老年胃癌组织中Gal-3和CA242表达阳性率分别为65．0％（39／60）和81．7％（49／60），均高于异型增生和癌旁正常胃黏膜组织（P〈0．05）。Gal-3和CA242表达与老年胃癌浆膜浸润、淋巴结转移和患者预后密切相关（P〈0．05）。Gal-3和CA242表达呈正相关（r=0．32，P〈0．05）。结论Gal-3和CA242表达与老年胃癌发生、转移和患者生存期密切相关，检测Gal．3和CA242蛋白表达可作为判断老年胃癌预后的参考指标。
Objective To investigate the expression of adhesion molecules galectin-3 （Gal-3） and CA242 protein in human gastric carcinoma in the aged and their relationship with the pathological behavior and prognosis. Methods Immunohistochemical staining was used to detect the expression of Gal-3 and CA242 protein in 60 cases of gastric carcinoma, 30 cases of gastric epithelial dysplasia and 20 cases of nor- mal gastric mucosa. The study was also combined with analysis of the pathological behavior and clinical fol- low-up survey of aged gastric carcinoma patients. Results The positive expression rate of Gal-3 and CA242 protein in gastric carcinoma was 65.0% （39/60） and 81.7% （49/60）, respectively. The positive rates of Gal-3 and CA242 in aged gastric carcinoma patients were higher than those in epithelial dysplasia and normal gastric mucosa （P 〈 0. 05）. The expression of Gal-3 and CA242 was closely related to serosa infiltration, lymph node metastasis and prognosis of patients （P 〈 0. 05）. Positive correlation was found between Gal-3 and CA242 protein （ r = 0. 32, P 〈 0. 05 ）. Conclusions The expression of Gal-3 and CA242 is closely related to carcinogenesis, metastasis and survival rate in aged gastric carcinoma pa- tients. Gal-3 and CA242 may be prognostic indicators of aged gastric carcinoma patients.
出处
《中国实用医刊》
2013年第10期43-45,共3页
Chinese Journal of Practical Medicine
