摘要
【目的】 为了探讨氟哌啶醇不同服法治疗多发性抽动症 (TS)的疗效及副作用。 【方法】 16 2例TS患儿随机分两组 :治疗组 87例 ,氟哌啶醇 0 .0 2 5～ 0 .0 5mg/kg .次 ,每天睡前顿服 ;对照组 75例 ,药物及每次量同前 ,每日三次 ,三个月一疗程。 【结果】 第一疗程治疗组显效 46例 ,进步 2 7例 ,有效率 83 .9% ;对照组显效 41例 ,进步2 3例 ,有效率 85 .3 % (P >0 .0 5 )。第二疗程有效率分别为 97.7%及 88.0 % (P <0 .0 5 )。两组症状治疗前及第一疗程后评分结果P均 >0 .0 5 ;第二疗程后评分分别为 (0 .6 78± 0 .70 5 )、(0 .9± 0 .83) ,P <0 .0 5。而副作用评分 :对照组12 4分 ,治疗组 9分 (t=19.91,P <0 .0 1)。 【结论】 说明治疗组疗效比对照组高 ,而副作用明显低于治疗组 ,差异非常显著。
Objective To explore the mechanism of effect and side effectof Tourett' syndrome treated with different doses of Haloperidol(HAL). Methods 162 patients of TS were randomly divided into two groups. There were 75 cases in the control group CG treated with HAL 0.025～0.05mg/kg.time,3 times one day for 3 months. There were 87 cases in the treatment group TG treated with HAL 0.025～0.05mg/kg.time, once a day, taked in before sleeping for 3 months. Results The effective rate of TG was 83.9% and that of CG was 85.3%. P >0.05 in first course treatment. The effective rate of TG was 97.7% and that of CG was 88.0%. P >0.05 in second course treatment. The score after treatment: The scores were (0.93±0.83) in CG,(0.678±0.705) in TG, P <0.05. The score of side effect in CG and TG was 1.65,0.094, P <0.01. Conclusion Therapeutic effect in TG was better than that in the CG, the side effect was less than that in CG,it was very significant difference between the two gtoups.
出处
《中国儿童保健杂志》
CAS
2000年第5期288-289,共2页
Chinese Journal of Child Health Care
