摘要
目的 :通过测定心肌梗死后大鼠的T淋巴细胞亚群 ,观察心肌梗死后大鼠免疫功能的变化 ,同时观察黄芩甙对其免疫功能的调节作用。方法 :结扎大鼠左冠脉前降支 ,饲养 4个月后取血作淋巴细胞数及其亚群分析。结果 :结扎冠脉 4个月后 ,大鼠血液中CD3 升高 ,但CD4 /CD8值显著降低 ,表明心肌梗死后大鼠的免疫功能紊乱 ,细胞免疫功能明显降低。给予黄芩甙后 (灌胃 ,40mg·kg-1·d-1) ,其血液中CD3、CD4 /CD8均接近正常。结论
Objective To observe the immunomodulating effect of baicalin on the rats with chronic myocardial infarction.Methods The rat anterior descending branch of left coronary artery was ligated and then the rats was raised.After 4 months the hemodynamics and electrocardiogram were monitored. The blood sample was taken to assay levels of T lymphocyte subpopulations.The myocardium was taken to microscopical examination.Results The ratio of CD 4/CD 8 was markedly lowered in rats with ischemic heart failure. Baicalin was able to raise the ratio of CD 4/CD 8 to near normal, improved myocardial structure and the contractile function of heart.Conclusion Baicalin has cardioprotective effect possibly via immunomodulating effects.
出处
《南京铁道医学院学报》
2000年第3期162-164,共3页
Journal of Nanjing Railway Medical College
基金
江苏省科委社会发展基金资助项目!(96036)
关键词
心肌梗死
淋巴细胞亚群
免疫调节作用
黄芩甙
myocardial infarction
sub lymphocytes
immunomodulating effects
baicalin
rats
