摘要
目的:观察三乙醇胺乳膏预防中晚期宫颈癌患者放射治疗致急性放射性皮肤损伤的临床疗效。方法:将84例需放射治疗的中晚期宫颈癌患者采用随机数字表法随机分为2组,用药组42例在第1次放射治疗后给予三乙醇胺乳膏涂抹上至脐平面、下至大腿上1/3、两侧至腋中线区域及臀部、骶尾部皮肤(包括会阴部、肛周及腹股沟区皮肤),对照组42例只做常规放射治疗宣教和健康教育。结果:两组皮肤损伤发生率均为100%。重度皮肤损伤(3、4级),用药组为9.6%(4/42),对照组为42.9%(18/42),两组差异具有统计学意义(P<0.05)。在照射剂量40Gy以前出现皮肤损伤,用药组为28.6%(12/42),对照组为95.2%(40/42)。两组差异具有统计学意义(P<0.05)。结论:三乙醇胺乳膏能有效降低中晚期宫颈癌放疗患者皮肤损伤的程度,提高皮肤的耐受性,推迟损伤出现的时间,保证放射治疗的顺利进行。
Objective： To observe the clinical effect of trolamine cream to prevent acute radiation-induced dermal injury in pa- tients with advanced cervical cancer. Methods： Eighty-four patients with advanced cervical cancer treated by radiotherapy were ran- domized into 2 groups. Patients in the treatment group （42 cases） were given trolamine cream since the first day of radiotherapy and pa- tients in the control group（42 cases ） were given routine education of radiotherapy and health care. Results：Dermal injury occurred in all the case in these two groups. The rate of severe dermal injury （3, 4 grade） was 9.6% （4/42） in treatment group and 42. 9% （ 18/42 ） in control group with significant difference（ P 〈 0. 05 ）. The rates of dermal injury before 40 Gy radiation dose was given were 28.6% （12/42） and 95.2% （40/42） in treatment group and control group respectively. There was significant difference （P 〈 0. 05 ）. Conclusion：Trolamine cream can effectively prevent radiation-induced dermal injury in patients with advanced cervical carcinoma. It can alleviate the patients＇ suffering and delay the occurrence of dermal injury, so as to ensure uneventful radiotherapy.
出处
《肿瘤预防与治疗》
2013年第2期83-85,共3页
Journal of Cancer Control And Treatment
关键词
宫颈癌
放射性皮肤损伤
三乙醇胺乳膏
Cervical Cancer
Radiation-induced Dermal Injury
Trolamine Cream
