摘要
目的通过免疫组织化学染色方法,检测凋亡抑制蛋白Livin在前列腺癌组织、前列腺增生组织表达情况,探讨Livin在前列腺癌组织表达及其意义,分析前列腺癌组织Livin表达与前列腺癌临床分期、Gleason评分的关系。方法收集我院35例经直肠前列腺穿刺或手术切除病理证实的前列腺癌组织石蜡标本,15例经手术切除病理证实的前列腺增生组织石蜡标本,通过免疫组织化学染色方法,检测Livin在前列腺癌组织、前列腺增生组织表达情况。结果 Livin在前列腺癌组织表达率94.29%(33/35),在前列腺增生组织表达率80.00%(12/15),前列腺癌组织Livin表达与前列腺增生组织表达的差异无统计学意义(P>0.05)。Livin在前列腺癌组织表达与患者术前前列腺特异性抗原(PSA)、是否远处转移、Gleason评分、临床分期无关(P>0.05)。结论 Livin在前列腺癌组织高表达,在前列腺癌发生可能起重要作用;但Livin在鉴定前列腺组织良恶性方面无明显作用。
Objective To detect expression of apoptosis inhibitory protein Livin in prostate cancer tissue and bemgn pros- tatic hyperplasia tissue by immunohistochemical staining method, study expression of Livin in prostate cancer tissue and benign prostatic hyperplasia tissue and its significance, and investigate the relationship of expression of Livin and clinical stage or Glea son score in prostate cancer. Methods Thirty-five cases of pathologically confirmed paraffin-embedded specimens of prostate cancer tissue by surgical resection or transrectal prostate biopsy were collected, 15 cases of pathologically confirmed paraffin-em- bedded specimens of prostate hyperplasia tissue by surgical resection in our hospital. By immunohistochemical staining method to detect expression of Livin in prostate cancer and benign prostatic hyperplasia. Results The positive expression rates of Livin were 94.29~ （33/35） in prostate cancer and 80.00% （12/15） in benign prostatic hyperplasia tissue. Expression of Livin had no significant difference in prostate cancer tissue and prostatic hyperplasia tissue （P〈0.05）. Expression of Livin in prostate cancer was unrelated with preoperative PSA, whether distant metastases, Gleason score or clinical stage （P〉0.05）. Conclu- sions Livin is high expressed in prostate cancer tissue, Livin may play an important role in the occurrence of prostate cancer. However, Livin in the identification of prostatic tissue of benign and malignant aspect has no significant role.
出处
《福建医药杂志》
CAS
2013年第2期80-83,共4页
Fujian Medical Journal
