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阿司匹林联合氯吡格雷加溶栓治疗急性心肌梗死临床观察 被引量:6

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摘要 目的探讨阿司匹林联合氯吡格雷加溶栓治疗急性心肌梗死临床疗效,观察分析。方法对我院收治的68例急性心肌梗死患者进行随机分为观察组与对照组,每组34例。对照组给予常规口服阿司匹林300mg进行抗血小板治疗;观察组在常规治疗的基础上加服首次氯吡格雷300mg,次日口服75mg,连用28d。观察患者血管再通率、再梗塞率与90d时心脏左室射血分数(LVEF)。溶栓药物选用静脉滴入尿激酶。结果观察组患者血管再通率明显高于对照组,差异具有统计学意义(P<0.05);观察组再梗塞率明显低于对照组,差异具有统计学意义(P<0.05);90d时心脏左室射血分数高于对照组,差异具有统计学意义(P<0.05)。结论阿司匹林联合氯吡格雷加溶栓治疗急性心肌梗死在近期或远期疗效均优于单纯使用阿司匹林。
作者 刘程光
出处 《中国实用医药》 2013年第11期175-176,共2页 China Practical Medicine
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  • 1张言镇,赵丽梅,柳林,赵新祥,蔡跃红,吴玉萍.阿司匹林联合氯吡格雷治疗ST段抬高型急性心肌梗死的临床研究[J].潍坊医学院学报,2006,28(2):110-114. 被引量:15
  • 2COMMIT(CIOpidogrel and Metoprolol in Myocardial Infarction Trial) col-laborative group.Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction:randomised placebo-controlled trial.Lancet,2005,366:1622-1632.
  • 3COMMIT (CIOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group.Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction:randomised placebo-controlled trial.Lancet,2005,366:1607-1621.
  • 4Sabatine MS,Cannon CP,Gibson CM,et al.Addition of clopidogrel to aspirin and fibrinolytic therapy formyocardial infarction with ST-segment elevation.N Engl J Med,2005,352:1179-1189.
  • 5CURE investigators.Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.NEJM,2001,345:494-502.
  • 6Angiolillo DJ,Fernández-Ortiz A,Bernardo E,et al.High clopidogrel loading dose during coronary stenting:effects on drug response and interindivid-ual variability.Eur Heart J,2004,25:1903-1910.
  • 7Yusuf S,ZhaoF,Mehta SR,et al.Effects ofclopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.N Engl J Med,2001,345:494-502.
  • 8Mehta SR,Yusuf S,Peters RJ,et al.Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention:the PCI-CURE study.Lancet,2001,358:527-533.
  • 9Steinhubl SR,Berger PB,Mann JT,et al.Early and sustained dualoral antiplatelet therapy following percutaneous coronary intervention:a randomized controlled trial.JAMA,2002,288:2411-2420.
  • 10Sabatine MS,Cannon CP,Gibson CM,et al.Addition of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial Infarction with ST-Segment Elevation.N Engl J Med,2005,352:1179-1189.

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