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Chiral ionic liquids as chiral selectors for separation of tryptophan enantiomers by ligand exchange chromatography 被引量:2

Chiral ionic liquids as chiral selectors for separation of tryptophan enantiomers by ligand exchange chromatography
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摘要 Chiral ionic liquids (CILs) containing imidazolium cations and L-Proline (L-Pro) anions were applied as chiral selector to separate tryptophan (Trp) enantiomers on a C18 column by ligand exchange chromatography. Several factors influencing Trp enantiomers separation, such as alkyl chain length of CILs, concentrations of Cu2+ and CILs, pH of the mobile phase, flow rate, organic solvent and temperature, were studied. Under the optimal conditions, the Trp enantiomers could be successfully separated within 21 min with the resolution of 2.30. At the same time, some thermodynamical parameters were obtained. The experimental results show that the enthalpy values of the Trp enantiomers are negative, indicating that the separation process is exothermic. And the enthalpy values of D-Trp are larger than those of L-Trp, which indicates that L-Trp could form more stable ternary complexes with tryptophan enantiomers. Chiral ionic liquids (CILs) containing imidazolium cations and L-Proline (L-Pro) anions were applied as chiral selector to separate tryptophan (Trp) enantiomers on a C18 column by ligand exchange chromatography. Several factors influencing Trp enantiomers separation, such as alkyl chain length of CILs, concentrations of Cu2+ and CILs, pH of the mobile phase, flow rate, organic solvent and temperature, were studied. Under the optimal conditions, the Trp enantiomers could be successfully separated within 21 min with the resolution of 2.30. At the same time, some thermodynamical parameters were obtained. The experimental results show that the enthalpy values of the Trp enantiomers are negative, indicating that the separation process is exothermic. And the enthalpy values of D-Trp are larger than those of L-Trp, which indicates that L-Trp could form more stable ternary complexes with tryptophan enantiomers.
出处 《Journal of Central South University》 SCIE EI CAS 2013年第5期1173-1177,共5页 中南大学学报(英文版)
基金 Project(21176262) supported by the National Natural Science Foundation of China Project(2010WK3029) supported by Science and Technology Program of Hunan Province,China
关键词 chiral ionic liquids chiral separation ligand exchange chromatography tryptophan enantiomers L-色氨酸 手性选择 色谱分离 配体交换 离子液体 对映体 对映异构体 L-脯氨酸
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参考文献27

  • 1CROSBY J. Synthesis of optically active compounds: A large scale perspective [J]. Tetrahedron, 1991,47(27): 4789-4846.
  • 2FANALI S. Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors [J]. Journal of Cbromatography A, 2000,875(1/2): 89-122.
  • 3HERRAEZ-HERNANDEZ R, CAMPINS-FALCO P. Chiral separation of ephedrines by liquid cbromatography using p-cyclodextrins [J]. Analytica Chimica Acta, 2001, 434(2): 315-324.
  • 4HEALYLO, MURRIHY JP, TAN A, COCKERD,MCENERYM, GLENNON J D. Enantiomeric separation of R, S-naproxen by conventional and nano-liquid cbromatography with methyl-beta?cyclodextrin as a mobile phase additive [J]. Journal of Chromatography A, 2001, 924(1): 459-464.
  • 5IVANYI R, JICSINSZKY L, JUVANCZ Z. Permethyl monoamino p-cyclodextrin a new chiral selective agent for capillary electrophoresis [J]. Cbromatographia, 2001, 53(3/4): 166-172.
  • 6PAWTOWSKA M, ZUKOWSKI J. Solvent-generated HPLC systems with p-cyelodextrin derivatives as chiral additives [J]. Microchim Acta, 1990, 102(1/3): 55-69.
  • 7HELDIN E, LINDNER K J, PETTERSIN C, LINDNER W, RAO R. Tartaric acid derivatives as chiral selectors in liquid cbromatography [J]. Chromatographia, 1991,32(9/10): 407-416.
  • 8周丹,刘佳佳,唐课文,黄可龙.Chiral extraction of ketoprofen enantiomers with chiral selector tartaric esters[J].Journal of Central South University of Technology,2007,14(3):353-356. 被引量:2
  • 9OEHRLE S A. Controlled changes in selectivity of cation separations by capillary electrophoresis using various crown-ether additives [J]. Journal of Chromatography A, 1996, 745(1/2): 87-92.
  • 10CHIOU C S, SHIH J S. Application of crown ethers as modifers for the separation of amines by capillary electrophoresis [J]. Analytica Chimica Acta, 1998,360(1/3): 69-76.

二级参考文献53

  • 1FANNIN A A,FLOREANI D A,KINGS L A,et al.[J].Phy Chem,1984,88:2614-2621.
  • 2WELTON T.[J].Chem Rev,1999,99:2071 -2083.
  • 3WASSERSCEID P,KEIM W.[J].Chem Int Ed,2000,39:3772 -3789.
  • 4GORDON C M.[J].Appl Catal A,2001,222:101 -117.
  • 5LIU J F,JONSSON J A,JIANG G B.[J].Trends in Anal Chem,2005,24:20 -27.
  • 6PANDEY S.[J].Anal Chim Acta,2006,556:38 -45.
  • 7VAHER M,KOEL M,KALJURAND M.[J].Chromatographia,2001,53:302 -306.
  • 8VAHER M,KOEL M,KALJURAND M.[J].J Chromatogr,A,2002,979:27 -32.
  • 9VAHER M,KOEL M.[J].J Chromatogr,A,2003,990:225-230.
  • 10YANES E G,GRATZ S R,BALDWIN M J,et al.[J].Anal Chem,2001,73:3838 -3844.

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