摘要
目的:基于针刺治疗原发性抑郁症(PDD)的高质量临床证据与层次分析法,获得针刺治疗MDD最优的干预方式。方法:计算机检索国内外医学文献数据库,全面收集针灸治疗PDD的高质量临床证据。按照Jadad评分法评价证据质量,采用RevMan 5.1软件进行Meta分析及效应量统计评价。对获得的临床证据采用层次分析法建构模型和矩阵,筛选最优针刺干预方式。结果:共纳入14项研究,Meta分析结果显示针刺与选择性5-羟色胺再摄取抑制剂(SSRIs)相比较在临床控制率、显效率、有效率及临床总有效率均无统计学差异,针刺配合SSRIs基础上可提高临床控制率及临床总有效率;最优干预方式以电针配合SSRIs干预6周达到最好整体疗效。结论:基于现阶段的临床证据,针刺治疗轻PDD应以电针配合SSRIs干预6周为最优干预方式,可显著提高临床控制率和临床总有效率。
Objective To acquire the optimal intervention methods of acupuncture on primary depressive disor-der （PDD） through high quality clinical evidences of acupuncture for PDD and analytic hierarchy process. Methods Databases of domestic and international medical literatures were retrieved with computer. And high-quality clinical evidences on treatment of PI）D with acupuncture were collected. Jadad scale evaluation was adopted to estimate the quality of evidences. RevMan 5.1 software was applied for Meta analysis and statislical appraisal on effect size. Analytic hierarchy process was utilized on acquired clinical evidences to construct the model and matrix to screen the optimal interevention method. Results Fourteen researches were included. And the result of Meta analysis showed that no statistical differences could be found on clinical control rate, marked effectiveness rate, effective rate and the overall clinical effective rate between acupuncture and selective serotonin reuptake inhibitor （SSRIs）. The combination of acupuncture and SSRIs could improve the clinical control rate and the overall clinical effective rate. And a 6-week intervention of electro acupuncture combined with SSRIs was considered as the best intervention for the best overall effect. Conclusion Based on the present clinical evidences, a 6-week intervention of acupuncture combined with SSRIs is the best intervention on mild or moderate PDD, which can obviously enhance the clinical control rate and the overall clinical effective rate.
出处
《中国针灸》
CAS
CSCD
北大核心
2013年第5期463-467,共5页
Chinese Acupuncture & Moxibustion
关键词
针刺
原发性抑郁症
META分析
层次分析法
临床决策
acupuncture
primary depressive disorder
meta analysis
analytic hierarchy process
clinical decision
