摘要
目的评估单纯性乳腺粘液癌（Puremucinousbreastcarcinoma，PMBC）的生物学行为。方法对1993--2011年问的610名满足入组条件的患者进行研究，其中494名为浸润性导管癌（Invasiveductal carcinoma，IDC），116名为PMBC。对临床生物学特点、总生存（Overallsurvival，OS）和无病生存率（Disease—freesurvival，DFS）进行比较。结果PMBC患者淋巴结阳性率低，TNM分期低，ER，PR表达水平高，Her-2表达水平低，进行术后化疗患者的比例较少。PMBC患者5年总生存率和无病生存率均高于IDC患者（P值为0．036和0．023）。多因素分析结果表明ER状态是影响的预后性因素。结论PMBC具有良好的组织学特征和预后，其中ER表达情况是影响预后的最重要因素。
Objective To compare PMBC and invasive ductal carcinoma（IDC） and to reliably assess the biologic behavior of PMBC. Methods A total of 610 patients who met the inclusion criteria were identified from 1993 to 2011 ;494 patients had pure IDC and 116 had PMBC. Clinical and biologic features, overall survival and disease - free survival （DFS） were compared for both groups. Results PMBC had favorable characteristics including lower rate of lymph node positivity, lower stage, higher expression of ER and PR, less Her - 2 overex- pression and less chemotherapy ＇after surgery. Patients with PMBC had better 5 - year OS and DFS than patients with IDC （P = 0.036 and 0.023, respectively）. Multivariate analysis revealed that ER status was statistically sig- nificant prognostic factor for survival. Conclusion PMBC has a favourable histological characteristics and prog- nostic result. The ER status is the most important single prognostic factor.
出处
《实用肿瘤学杂志》
CAS
2013年第2期149-155,共7页
Practical Oncology Journal
关键词
乳腺癌
单纯性粘液癌
浸润性导管癌
预后
ER
Breast cancer
Pure mucinous breast carcinoma
Invasive ductal carcinoma
Prognosis
ER
