摘要
目的:观察全身化疗基础上加γ-干扰素雾化吸入治疗多耐药肺结核的临床疗效。方法:选取32例患者,分为观察组和对照组,对两组患者均给予全身化疗,观察组在化疗同时,雾化吸入γ-干扰素,观察疗效。结果:在治疗6个月和治疗结束,观察组的痰细菌学检查阴转率(分别为75%和100%)均高于对照组,差异有统计学意义(P<0.05);治疗结束时,观察组病灶吸收率(93.75%)显著高于对照组(62.50%),差异有统计学意义(P<0.05);观察组空洞缩小率(93.75%)高于对照组(68.75%),差异无统计学意义(P>0.05),观察组症状改善率(68.75%)高于对照组(31.25%),差异有统计学意义(P<0.05)。结论:γ-干扰素联合全身化疗治疗多耐药肺结核效果强于单纯全身化疗。
Objective: To observe clinical effects of treatment of multi-drug-resistant tuberculosis by systemic chemotherapy based on atomizing inhalation of γ-interferon. Method: 32 patients were divided into observation group and control group, two groups of were treated with systemic chemotherapy, and patients of observation plus atomizing inhalation of γ-interferon, then effects were observed. Result: Sputum bacteriology negative rates of the observation group ( respectively 75% and 100% ) at the six-month of the treatment and end-of-treatment were higher than that in the control group, the difference was statistically significant ( P〈0.05 ) ; end of treatment, loci absorption of the observation group ( 93.75% ) was significantly higher than that of the control group ( 62.50% ), and the difference was statistically significant ( P〈0.05 ) ; cavity narrowing rate of observation group ( 93.75% ) higher than that of the control group ( 68.75% ), although the difference was not statistically significant ( P〉 0.05 ), the observation group symptom improvement rate ( 68.75% ) higher than control group ( 31.25% ), the difference was statistically significant ( P〈0.05 ) . Conclusion: γ-Interferon in combine with chemotherapy for treatment of multi-drug-resistant tuberculosis is more effective than chemotherapy alone.
出处
《中国医学创新》
CAS
2013年第13期39-40,共2页
Medical Innovation of China
关键词
Γ-干扰素
肺结核
全身化疗
γ-interferon
Tuberculosis
Systemic chemotherapy