摘要
目的 探讨血清血管紧张素Ⅱ（AngⅡ）、超敏C反应蛋白（hs-CRP）和脑钠肽（BNP）水平与心房颤动的关系及临床意义,以及影响心房颤动复发的危险因素。方法 选取100例心房颤动的患者,分为阵发性房颤组54例,持续性房颤组46例,并与50例对照组比较分析。应用放射免疫法检血清AngⅡ及BNP水平,免疫比浊法检测hs-CRP水平。结果 心房颤动组血清AngⅡ、hs-CRP和BNP水平均显著高于对照组（均P＜0.01）,且持续性房颤组中AngⅡ、hs-CRP显著高于阵发性房颤组（P＜0.01）;线性相关分析表明AngⅡ、hs-CRP水平与BNP水平呈明显正相关（r=0.563、0.678,均P＜0.01）;AngⅡ水平与hs-CRP水平呈正相关（r=0.626,P＜0.01）;Logistic回归分析结果表明,hs-CRP、BNP与心房颤动复发关系密切［OR值=2.42,95%CI（1.84～5.26）;OR值=2.14,95%CI（1.37～3.86）］。结论 AngII、hs-CRP及BNP在心房颤动发生、发展过程中可能起重要作用,血清hs-CRP和BNP可能是心房颤动的独立危险因素,联合检测对心房颤动的复发有一定的预测作用。
Objective To explore the clinical signifcance of changes of serum AngII,hs-CRP and BNP levels and the relationship with atrial fibrillation（AF）,and the risk factors of AF recurrence.Methods 100 patients with AF were selected in this study,and they were divided into two groups：paroxysmal atrial fibrillation group（n=54）,durative atrial fibrillation group（n=46）,and 50 healthy subjects were selected as control.The levels of serum AngⅡ,BNP were detected by radioimmunoassay,and hs-CRP was detected by immunoturbidimetry.Results The levels of AngⅡ,hs-CRP and BNP in atrial fibrillation patients were significantly increased as compared to control group（P〈0.01）.The levels of AngⅡ,hs-CRP in the durative atrial fibrillation group were higher than those in the paroxysmal atrial fibrillation group.The levels of serum AngⅡ,hs-CRP were positively correlated with serum BNP level（r=0.563,0.678,all P〈0.01）.The level of serum AngⅡ was positively correlated with serum hs-CRP level（r=0.626,P〈0.01）.Multiple logistic regression analysis revealed that hs-CRP and BNP were the important risk factors of atrial fibrillation recurrence[OR value =2.42,95%CI（1.84~5.26）;OR value =2.14,95%CI（1.37~.86）].Conclusion The serum AngII,hs-CRP and BNP may play important roles in the development of AF.hs-CRP and BNP may be the independent risk factors of AF.The detection of hs-CRP and BNP may be related to recurrence prognosis in patients with AF.
【Key words】 Atrial fibrillation;Angiotensin II;C-Reactive protein;Natrinuretic peptide,brain
出处
《中国基层医药》
CAS
2013年第10期1497-1499,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心房颤动
血管紧张素Ⅱ
C反应蛋白质
利钠肽
脑
Atrial fibrillation
Angiotensin II
C-Reactive protein
Natrinuretic peptide, brain
