摘要
目的探讨帕金森病(Parkinson’Sdisease,PD)患者生活质量变化及其预测因素。方法收集2007年4—12月我院门诊就诊及住院的PD患者,最终符合条件患者81例。人组时收集患者病史及进行神经系统检查,并应用统一帕金森病评分量表(UPDRS)、Hoehn-Yahr(H-Y)分期量表、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HRSD)、简易精神状态量表(MMSE)、帕金森睡眠量表(PDSS)、Epworth嗜睡量表(ESS)评估患者的临床症状,运用帕金森病生活质量问卷(PDQ-39)评估患者的生活质量。在收集患者资料的基础上对患者进行随访,随访3年后对患者再次进行评估。结果随访末患者UPDRS总分(UPDRS-T)、UPDRS运动评分(UPDRSⅢ)、H—Y分级、PDQ-39评分分别为(52.65±18.03)分、(29.91±11.58)分、(2.51±0.80)级、(45.10±20.63)分,较基线(31.23±15.66)分、(20.59±10.73)分、(2.15±0.81)级、(26.62±18.39)分均增加(t=16.79、5.94、3.44、21.67,均P〈0.05),PD患者病情进展,患者生活质量下降。PDQ-39增加的分数与衡量患者病情的uPDRS和H—Y增长值相关(r=0.255、0.280,均P〈0.05);多元回归分析显示,影响PD患者生活质量的主要因素为抑郁(0R=1.223,P=0.005)。结论帕金森病患者生活质量随病程不断恶化。高抑郁评分是生活质量恶化的重要预测因素,应早期发现并及时干预。
Objective To investigate the changes of life quality in Parkinson's disease patients and the predictive factors. Methods A total of 81 patients in our hospital from April to December 2007 were involved. Medical history was collected and the nervous system was examined. The clinical characteristic was assessed by unified Parkinson's disease rating scale(UPDRS), Hoehn-Yahr stage, Hamilton anxiety scale(HAMA), Hamilton depression scale(HRSD), mini-mental state examination (MMSE). The quality of life in Parkinson's disease was assessed by using PDQ-39 questionnaire. After 3 years follow-up, the patients were assessed by these questionnaires again. Results The scores of UPDRS-T, UPDRS Ⅲ, Hoehn-Yahr stage, PDQ-39 at 3-year follow-up were increased remarbably compared with the baseline [(52.65±18.03), (29.91±11.58), (2. 51±0.80), (45.10±20.63) vs. (31.23±15.66), (20. 59±10.73), (2. 15±0.81), (26. 62±18.39), respectiely, t= 16.79, 5.94, 3.44, 21.67, all P〈0. 05]. With the deterioration in Parkinson's disease, the quality of life of the patients were decreased significantly. There was a positive relationship of △ PDQ-39 with △ UPDRS and △ H-Y (r= 0. 255,0. 280, both P〈0.05). Multiple regression analysis showed that the main factor affecting the quality of life in the Parkinson's disease was depression (OR = 2. 216, P= 0. 005). Conclusions With the deterioration in Parkinson's disease, the quality of life is decreased significantly. Depression is the important predictor of quality of life in Parkinson's disease.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第4期353-356,共4页
Chinese Journal of Geriatrics
基金
国家自然科学基金(81071025、81171203)
上海市科技委员会项目(11nm0503300、11410708900、12XD1403800)
上海市教育委员会项目(10ZZ72)
关键词
帕金森病
生活质量
抑郁
前瞻性研究
Parkinson disease
Quality of life
Depression
Prospective studies