抗缪勒管激素对卵巢功能的调节及预测作用被引量：13

Anti-Müllerrian Hormone:Regulator and Marker of Ovarian Function

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摘要新型特异性抗缪勒管激素(AMH)抗体的出现使血清AMH浓度的测量更为精确。AMH由晚期窦前卵泡及小窦状卵泡的颗粒细胞分泌,其可抑制原始卵泡向初级卵泡的转化。女性AMH浓度随着年龄增长而下降,在绝经后无法测量到。相对于其他的生物化学及生物物理的检测指标而言,AMH在评估卵巢储备功能上有许多的优点,AMH的表达并不依赖于下丘脑-垂体-卵巢轴。因此,在整个月经周期中其血清浓度均保持稳定。血清AMH浓度可精确反映卵泡的储备情况,因此被认为是一个预测卵巢储备的灵敏指标。 Development of novel antibodies directed against anti-Mtillerian hormone（AMH） has allowed more accurate measurement of AMH in serum. AMH is secreted by granulosa ceils in late preantral and small antral follicles, which inhibits the transition from the primordial to the primary follicular stage. In women ser- um AMH levels decrease with age and are undetectable in the post-menopausal period. AMH measurement allows an assessment of ovarian reserve with several advantages over other biochemical and biophysical mark- ers as serum AMH levels are independent from hypothalarnic-pituitary-ovarian axis function, therefore the lev- el of AMH remains stable throughout the menstrual cycle. Serum AMH concentration can accurately reflect fnllicl reserve_therefore it is considered as a sensitive marker to predict ovarian reserves.

作者陈玲项双卫

机构地区福建医科大学协和临床医学院福建医科大学附属协和医院妇产科

出处《医学综述》 2013年第8期1400-1402,共3页 Medical Recapitulate

关键词抗缪勒管激素卵巢储备卵巢早衰 Anti-Mllllerian hormone Ovarian reserve Premature ovarian lailure

分类号 R711 [医药卫生—妇产科学]

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