摘要
地方性氟中毒是由于地球化学性因素导致某一地区的居民长期从外界环境中摄入大量的氟所引起的以骨骼损害为主的全身性地球化学性疾病。氟骨症是地方性氟中毒最严重的临床表现之一,其普遍存在于氟、砷联合污染病区的人群中。近年来发现,氟骨症患者通常存在氟、砷联合中毒,且发现砷可加重氟骨症,但砷以何种机制影响氟骨症发生尚不清楚。为了降低氟骨症的发病率及对氟骨症患者实施有效的治疗,研究氟骨症的发病机制非常重要。
Endemic fluorosis is a global systemic chemical disease with skeletal damage as the main damage of residents in a certain area resulted from long term intake of massive fluoride from the external envi- ronment due to the geochemical factors. Skeletal fluorosis, one of the most serious clinical manifestations of endemic fluorosis,is prevalent in the crowd of fluorine, arsenic joint pollution area. The phenomenon that skeletal fluorosis patients usually present fluoride-arsenic poisoning is discovered in recent years. Moreover, arsenic is found to play an aggravating role in skeletal fluorosis. But the mechanism of aggravating skeletal fluorosis by affect is not well understood. In order to reduce the prevalence of skeletal fluorosis and give effec- tive treatment to the patients,it is important to study the pathogenesis of skeletal fluorosis.
出处
《医学综述》
2013年第8期1426-1429,共4页
Medical Recapitulate
基金
贵州省科技厅社会发展攻关项目(黔科合SY字〔2012〕3125号)
关键词
氟
砷
氟砷联合中毒
骨骼
Fluorine
Arsenic
Fluoride-arsenic poisoning
Skeleton
